{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T11:22:09Z","timestamp":1710933729443},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,3,26]],"date-time":"2009-03-26T00:00:00Z","timestamp":1238025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p>Anti\u2010tuberculosis drug resistance levels and patterns of <jats:italic>Mycobacterium tuberculosis<\/jats:italic> (<jats:italic>Mtb<\/jats:italic>) isolated from newly diagnosed tuberculosis (TB) patients in Temeke district in Dar es Salaam, Tanzania were investigated. A total of 226 <jats:italic>Mtb<\/jats:italic> isolates from 564 TB suspects with no previous history of anti\u2010TB treatment were tested for drug resistance against rifampicin, isoniazid, streptomycin and ethambutol on Lowenstein Jensen (LJ) medium using the proportion method. Of the 226 isolates, 22 (9.7%) were resistant to any one of the four anti\u2010TB drugs; nine (3.99%) isolates were isoniazid mono\u2010drug resistant and eight (3.54%) isolates were streptomycin mono\u2010drug resistant. Multi\u2010drug resistance, defined as resistance to both rifampicin and isoniazid, was observed in three (1.3%) isolates and two were also resistant to streptomycin and ethambutol. One (0.44%) isolate had poly resistance to isoniazid and streptomycin. The level of anti\u2010TB drug resistant <jats:italic>Mtb<\/jats:italic> in Temeke, an HIV endemic area, remained constant between 1995 and 2007. The level of resistance to any one of the four anti\u2010TB drugs was between 9.0% and 10%, resistance to individual drugs &lt;4% and multi\u2010drug resistance &lt;2%.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2008.02429.x","type":"journal-article","created":{"date-parts":[[2009,3,26]],"date-time":"2009-03-26T15:44:09Z","timestamp":1238082249000},"page":"263-267","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anti\u2010TB drug resistance levels and patterns among <i>Mycobacterium tuberculosis<\/i> isolated from newly diagnosed cases of pulmonary tuberculosis in Dar es Salaam, Tanzania"],"prefix":"10.1111","volume":"117","author":[{"given":"MECKY","family":"MATEE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SAYOKI","family":"MFINANGA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CAROL","family":"HOLM\u2010HANSEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,26]]},"reference":[{"key":"e_1_2_7_2_2","volume-title":"Global Tuberculosis Control: Surveillance, Planning, Financing. 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