{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:56:42Z","timestamp":1790409402988,"version":"4.1.0"},"reference-count":166,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p> <jats:italic>Mycobacterium tuberculosis<\/jats:italic>, the causative agent of tuberculosis (TB), remains a major worldwide health problem that causes more than 2 million deaths annually. In addition, an estimated 2 billion people are latently infected with <jats:italic>M. tuberculosis<\/jats:italic>. The bacterium is one of the oldest human pathogens and has evolved complex strategies for survival. Therefore, to be successful in the high endemic regions, any future TB vaccine strategy will have to be tailored in accordance with the resulting complexity of the TB infection and anti\u2010mycobacterial immune response. In this review, we will discuss what is presently known about the interaction of <jats:italic>M. tuberculosis<\/jats:italic> with the immune system, and how this knowledge is used in new and more advanced vaccine strategies.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2009.02458.x","type":"journal-article","created":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T11:39:31Z","timestamp":1240313971000},"page":"440-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Interaction of <i>Mycobacterium tuberculosis<\/i> with the host: consequences for vaccine development"],"prefix":"10.1111","volume":"117","author":[{"given":"JES","family":"DIETRICH","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. MARK","family":"DOHERTY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,21]]},"reference":[{"key":"e_1_2_10_2_2","volume-title":"Global Tuberculosis Control \u2013 Surveillance, Planning, Financing. WHO: World Health Organization","author":"Anon.","year":"2008"},{"key":"e_1_2_10_3_2","first-page":"71","article-title":"The global tuberculosis situation and the new control strategy of the World Health Organization. 1991","volume":"79","author":"Kochi A.","year":"2001","journal-title":"Bull World Health Organ"},{"issue":"3","key":"e_1_2_10_4_2","first-page":"S47","article-title":"Impact of the HIV epidemic on the spread of other diseases","volume":"14","author":"Girardi E","year":"2000","journal-title":"the case of tuberculosis"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.79.10.1358"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7018.1468"},{"key":"e_1_2_10_7_2","first-page":"483","article-title":"Towards universal access to HIV prevention, treatment, care, and support","volume":"6","author":"Reid A","year":"2006","journal-title":"the role of tuberculosis\/HIV collaboration"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.1.7812542"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2007.04.001"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000200543.80712.01"},{"key":"e_1_2_10_11_2","first-page":"67","article-title":"The immune reconstitution inflammatory syndrome","volume":"5","author":"Shelburne SA","year":"2003","journal-title":"AIDS Rev"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70260-3"},{"key":"e_1_2_10_13_2","first-page":"29","article-title":"The efficacy of bacillus Calmette\u2013Guerin vaccination of newborns and infants in the prevention of tuberculosis","volume":"96","author":"Colditz GA","year":"1995","journal-title":"meta-analyses of the published literature"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510330076038"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1211"},{"key":"e_1_2_10_16_2","first-page":"717","article-title":"Efficacy of the BCG revaccination programme in a cohort given BCG vaccination at birth in Hong Kong","volume":"5","author":"Leung CC","year":"2001","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_10_17_2","first-page":"1290","article-title":"Effect of BCG revaccination on incidence of tuberculosis in school\u2010aged children in Brazil","volume":"366","author":"Rodrigues LC","year":"2005","journal-title":"the BCG-REVAC cluster-randomised trial"},{"key":"e_1_2_10_18_2","first-page":"672","article-title":"Failure of the Mycobacterium bovis BCG vaccine","volume":"70","author":"Brandt L","year":"2002","journal-title":"some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1722-1728.2001"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425332"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2004.04.016"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(02)00355-2"},{"key":"e_1_2_10_23_2","first-page":"452","article-title":"The evolution of mycobacterial pathogenicity","volume":"9","author":"Brosch R","year":"2001","journal-title":"clues from comparative genomics"},{"key":"e_1_2_10_24_2","first-page":"541","article-title":"Tuberculosis","volume":"4","author":"De Jonge MI","year":"2005","journal-title":"from genome to vaccine"},{"key":"e_1_2_10_25_2","first-page":"388","article-title":"Tuberculosis in HIV\u2010infected patients","volume":"10","author":"Aaron L","year":"2004","journal-title":"a comprehensive review"},{"key":"e_1_2_10_26_2","first-page":"175","article-title":"The prognosis of latent tuberculosis","volume":"13","author":"Andersen P","year":"2007","journal-title":"can disease be predicted?"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/82139"},{"key":"e_1_2_10_28_2","first-page":"359","article-title":"Tuberculosis and latent tuberculosis infection in close contacts of people with pulmonary tuberculosis in low\u2010income and middle\u2010income countries","volume":"8","author":"Morrison J","year":"2008","journal-title":"a systematic review and meta-analysis"},{"key":"e_1_2_10_29_2","first-page":"97","article-title":"Tuberculosis","volume":"1","author":"Stewart GR","year":"2003","journal-title":"a problem with persistence"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.10.5676-5686.2004"},{"key":"e_1_2_10_31_2","first-page":"1635","article-title":"Cutting edge","volume":"170","author":"Appelmelk BJ","year":"2003","journal-title":"carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells"},{"key":"e_1_2_10_32_2","first-page":"697","article-title":"DC\u2010SIGN","volume":"3","author":"Van Kooyk Y","year":"2003","journal-title":"escape mechanism for pathogens"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1107742"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2001.00844.x"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(00)01919-3"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-9792(02)00089-6"},{"key":"e_1_2_10_37_2","first-page":"391","article-title":"Mycobacterial lipoarabinomannan and related lipoglycans","volume":"53","author":"Briken V","year":"2004","journal-title":"from biogenesis to modulation of the immune response"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1054\/tube.2002.0331"},{"key":"e_1_2_10_39_2","first-page":"371","article-title":"Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease","volume":"36","author":"Hunter RL","year":"2006","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2001.tb01319.x"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2003.tb03404.x"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1177\/09680519020080060101"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.11.6603-6614.2004"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.10.6272"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2007.00218.x"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.07.042"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01212.x"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1468"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.9.5511-5514.2004"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02837"},{"key":"e_1_2_10_51_2","first-page":"1087","article-title":"Intracellular signalling cascades regulating innate immune responses to Mycobacteria","volume":"9","author":"Jo EK","year":"2007","journal-title":"branching out from Toll-like receptors"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.06.006"},{"key":"e_1_2_10_53_2","first-page":"15","article-title":"MyDths and un\u2010TOLLed truths","volume":"116","author":"Reiling N","year":"2008","journal-title":"sensor, instructive and effector immunity to tuberculosis"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.4.2101-2110.2004"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00705.x"},{"key":"e_1_2_10_56_2","first-page":"569","article-title":"Mycobacterium tuberculosis","volume":"2","author":"Russell DG.","year":"2001","journal-title":"here today, and here tomorrow"},{"key":"e_1_2_10_57_2","first-page":"2002","article-title":"Pathogen destruction versus intracellular survival","volume":"118","author":"Steinberg BE","year":"2008","journal-title":"the role of lipids as phagosomal fate determinants"},{"key":"e_1_2_10_58_2","first-page":"71","article-title":"A tale of two lipids","volume":"7","author":"Chua J","year":"2004","journal-title":"Mycobacterium tuberculosis phagosome maturation arrest"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-007-0076-1"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2007.00547.x"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8303277"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31947"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00412-08"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00721.x"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409716102"},{"key":"e_1_2_10_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2008.01147.x"},{"key":"e_1_2_10_67_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26226-0"},{"key":"e_1_2_10_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.10.006"},{"key":"e_1_2_10_69_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088063"},{"key":"e_1_2_10_70_2","first-page":"225","article-title":"Pseudo\u2010rationale design of efficient TB vaccines","volume":"86","author":"Hovav AH","year":"2006","journal-title":"lesson from the mycobacterial 27-kDa lipoprotein"},{"key":"e_1_2_10_71_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3146-3154.2003"},{"key":"e_1_2_10_72_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2008\/019968-0"},{"key":"e_1_2_10_73_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002375"},{"key":"e_1_2_10_74_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030186"},{"key":"e_1_2_10_75_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.312.5782.1874b"},{"key":"e_1_2_10_76_2","first-page":"1134","article-title":"Local production of nitric oxide in patients with tuberculosis","volume":"8","author":"Schon T","year":"2004","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_10_77_2","first-page":"87","article-title":"Nitric oxide","volume":"43","author":"Green SJ","year":"1994","journal-title":"cytokine-regulation of nitric oxide in host resistance to intracellular pathogens"},{"key":"e_1_2_10_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830251025"},{"key":"e_1_2_10_79_2","first-page":"838","article-title":"Contribution of alpha\/beta and gamma\/delta T lymphocytes to immunity against Mycobacterium bovis bacillus Calmette Guerin","volume":"25","author":"Ladel CH","year":"1995","journal-title":"studies with T cell receptor-deficient mutant mice"},{"key":"e_1_2_10_80_2","first-page":"527","article-title":"CD1 molecules and CD1\u2010dependent T cells in bacterial infections","volume":"12","author":"Schaible UE","year":"2000","journal-title":"a link from innate to acquired immunity?"},{"key":"e_1_2_10_81_2","first-page":"416","article-title":"CD1 proteins","volume":"2","author":"Ulrichs T","year":"2000","journal-title":"targets of T cell recognition in innate and adaptive immunity"},{"key":"e_1_2_10_82_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-69511-0_9"},{"key":"e_1_2_10_83_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636220"},{"key":"e_1_2_10_84_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425368"},{"key":"e_1_2_10_85_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5368.1435"},{"key":"e_1_2_10_86_2","doi-asserted-by":"publisher","DOI":"10.1086\/422693"},{"key":"e_1_2_10_87_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.2243"},{"key":"e_1_2_10_88_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.2249"},{"key":"e_1_2_10_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2004.09.011"},{"key":"e_1_2_10_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-8749(02)00510-5"},{"key":"e_1_2_10_91_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.3.347"},{"key":"e_1_2_10_92_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.2.1107"},{"key":"e_1_2_10_93_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.7.4296"},{"key":"e_1_2_10_94_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v26.i4.30"},{"key":"e_1_2_10_95_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.4.2042"},{"key":"e_1_2_10_96_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.7.3898"},{"key":"e_1_2_10_97_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2005.25.694"},{"key":"e_1_2_10_98_2","doi-asserted-by":"publisher","DOI":"10.1086\/513769"},{"key":"e_1_2_10_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(03)00303-1"},{"key":"e_1_2_10_100_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.01785.x"},{"key":"e_1_2_10_101_2","doi-asserted-by":"publisher","DOI":"10.1086\/511277"},{"key":"e_1_2_10_102_2","doi-asserted-by":"publisher","DOI":"10.1086\/422532"},{"key":"e_1_2_10_103_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001522"},{"key":"e_1_2_10_104_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.11.6938"},{"key":"e_1_2_10_105_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01932-06"},{"key":"e_1_2_10_106_2","first-page":"1578","article-title":"Longitudinal tracking of cytokines after acute exposure to tuberculosis","volume":"14","author":"Hussain R","year":"2007","journal-title":"association of distinct cytokine patterns with protection and disease development"},{"key":"e_1_2_10_107_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00602-06"},{"key":"e_1_2_10_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2007.02.002"},{"key":"e_1_2_10_109_2","first-page":"683","article-title":"Tuberculosis associated with blocking agents against tumor necrosis factor\u2010alpha \u2013 California, 2002\u20132003","volume":"53","author":"Anon.","year":"2004","journal-title":"Morb Mortal Wkly Rep"},{"key":"e_1_2_10_110_2","first-page":"2122","article-title":"Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk","volume":"48","author":"Gomez\u2010Reino JJ","year":"2003","journal-title":"a multicenter active-surveillance report"},{"key":"e_1_2_10_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90001-2"},{"key":"e_1_2_10_112_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.59.9.3021-3025.1991"},{"key":"e_1_2_10_113_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.3.1230"},{"key":"e_1_2_10_114_2","first-page":"213","article-title":"Role of cytokines in immune response to pulmonary tuberculosis","volume":"19","author":"Sharma S","year":"2001","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_10_115_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01341.x"},{"key":"e_1_2_10_116_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.1.103"},{"key":"e_1_2_10_117_2","doi-asserted-by":"publisher","DOI":"10.1086\/593174"},{"key":"e_1_2_10_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.038"},{"key":"e_1_2_10_119_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270945"},{"key":"e_1_2_10_120_2","first-page":"375","article-title":"Role of mycobacteria\u2010induced monocyte\/macrophage apoptosis in the pathogenesis of human tuberculosis","volume":"9","author":"Bocchino M","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_10_121_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.10.6973"},{"issue":"4","key":"e_1_2_10_122_2","first-page":"24","article-title":"Immunological control of tuberculosis","volume":"64","author":"Stenger S.","year":"2005","journal-title":"role of tumour necrosis factor and more"},{"key":"e_1_2_10_123_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.1.298-304.1997"},{"key":"e_1_2_10_124_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.4264-4273.2000"},{"key":"e_1_2_10_125_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.9.6245"},{"key":"e_1_2_10_126_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.5.1793-1799.1997"},{"key":"e_1_2_10_127_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199701)181:1<31::AID-PATH722>3.0.CO;2-G"},{"key":"e_1_2_10_128_2","first-page":"345","article-title":"Macrophage and T lymphocyte apoptosis during experimental pulmonary tuberculosis","volume":"36","author":"Rios\u2010Barrera VA","year":"2006","journal-title":"their relationship to mycobacterial virulence"},{"key":"e_1_2_10_129_2","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2001.5037"},{"key":"e_1_2_10_130_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200002)190:2<211::AID-PATH530>3.0.CO;2-3"},{"key":"e_1_2_10_131_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-008-9107-5"},{"key":"e_1_2_10_132_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1654"},{"key":"e_1_2_10_133_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.02080.x"},{"key":"e_1_2_10_134_2","first-page":"1101","article-title":"Tuberculosis","volume":"9","author":"Porcelli SA","year":"2008","journal-title":"unsealing the apoptotic envelope"},{"key":"e_1_2_10_135_2","first-page":"123","article-title":"Genetic dissection of host resistance to Mycobacterium tuberculosis","volume":"321","author":"Kramnik I.","year":"2008","journal-title":"the sst1 locus and the Ipr1 gene"},{"key":"e_1_2_10_136_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0505250"},{"key":"e_1_2_10_137_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2008.01194.x"},{"key":"e_1_2_10_138_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030110"},{"key":"e_1_2_10_139_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.6.2536-2544.1994"},{"key":"e_1_2_10_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(11)80460-2"},{"key":"e_1_2_10_141_2","first-page":"1539","article-title":"Tuberculosis subunit vaccines","volume":"7","author":"Doherty TM","year":"2007","journal-title":"from basic science to clinical testing"},{"key":"e_1_2_10_142_2","doi-asserted-by":"publisher","DOI":"10.1086\/425931"},{"key":"e_1_2_10_143_2","first-page":"635","article-title":"Tuberculosis","volume":"7","author":"Ly LH","year":"2008","journal-title":"vaccines in the pipeline"},{"key":"e_1_2_10_144_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2004.09.009"},{"key":"e_1_2_10_145_2","first-page":"531","article-title":"The secreted antigens of Mycobacterium tuberculosis and their relationship to those recognized by the available antibodies","volume":"134","author":"Abou\u2010Zeid C","year":"1988","journal-title":"J Gen Microbiol"},{"key":"e_1_2_10_146_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1992.tb03144.x"},{"key":"e_1_2_10_147_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652407780598566"},{"key":"e_1_2_10_148_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02779.x"},{"key":"e_1_2_10_149_2","first-page":"228","article-title":"Stationary phase gene expression of Mycobacterium tuberculosis following a progressive nutrient depletion","volume":"84","author":"Hampshire T","year":"2004","journal-title":"a model for persistent organisms?"},{"key":"e_1_2_10_150_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.121172498"},{"key":"e_1_2_10_151_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050075"},{"key":"e_1_2_10_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6616(03)00210-9"},{"key":"e_1_2_10_153_2","first-page":"4531","article-title":"Reactivation of latent tuberculosis","volume":"67","author":"Scanga CA","year":"1999","journal-title":"variations on the Cornell murine model"},{"key":"e_1_2_10_154_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27284-0"},{"key":"e_1_2_10_155_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.6.2062-2069.1996"},{"key":"e_1_2_10_156_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00918-06"},{"key":"e_1_2_10_157_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001502"},{"key":"e_1_2_10_158_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652407780598548"},{"key":"e_1_2_10_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2004.02.003"},{"key":"e_1_2_10_160_2","first-page":"4265","article-title":"Mycobacterial bacilli are metabolically active during chronic tuberculosis in murine lungs","volume":"189","author":"Talaat AM","year":"2007","journal-title":"insights from genome-wide transcriptional profiling"},{"key":"e_1_2_10_161_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2008.01.007"},{"key":"e_1_2_10_162_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.5.2985-2995.2006"},{"key":"e_1_2_10_163_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.06078.x"},{"key":"e_1_2_10_164_2","doi-asserted-by":"publisher","DOI":"10.1038\/35021074"},{"key":"e_1_2_10_165_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2007.1138"},{"key":"e_1_2_10_166_2","first-page":"687","article-title":"Vaccines for tuberculosis","volume":"18","author":"Doherty TM","year":"2005","journal-title":"novel concepts and recent progress"},{"key":"e_1_2_10_167_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1419"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0463.2009.02458.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0463.2009.02458.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T17:19:53Z","timestamp":1693502393000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0463.2009.02458.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,21]]},"references-count":166,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.1111\/j.1600-0463.2009.02458.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0463.2009.02458.x","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,21]]},"assertion":[{"value":"2009-04-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}