{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:43:22Z","timestamp":1760298202598},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,11,17]],"date-time":"2009-11-17T00:00:00Z","timestamp":1258416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>Jha HC, Srivastava P, Divya A, Prasad J, Mittal A. Prevalence of <jats:italic>Chlamydophila pneumoniae<\/jats:italic> is higher in aorta and coronary artery than in carotid artery of coronary artery disease patients. APMIS 2009; 117: 905\u201311.<\/jats:p><jats:p>Coronary artery disease (CAD) is a public health problem accounting for an estimated one\u2010third of deaths overall. A potential link between infectious agents and atherosclerosis has been suggested. Data obtained from several seroepidemiological studies have suggested that infection with <jats:italic>Chlamydiophila pneumoniae<\/jats:italic>, <jats:italic>Helicobacter pylori<\/jats:italic>, cytomegalovirus and herpes simplex virus\u20101 can initiate or maintain the atherosclerotic process. However, there is no single study in which multiple infectious agents have been detected together in different vascular locations in the same population. This would help in determining if there is any leading pathogen in atheromatous plaques of CAD patients. Hence, we screened for <jats:italic>C.\u00a0pneumoniae<\/jats:italic>, <jats:italic>H.\u00a0pylori<\/jats:italic>, CMV and HSV\u20101 in different vascular locations of CAD patients using quantitative real\u2010time (RT) PCR. We performed multiplex RT\u2010PCR for detecting pathogens, viz. <jats:italic>C.\u00a0pneumoniae<\/jats:italic>, <jats:italic>H.\u00a0pylori<\/jats:italic>, CMV and HSV\u20101 in different vascular locations of CAD patients. Percent positivity scores for <jats:italic>C.\u00a0pneumoniae<\/jats:italic>, <jats:italic>H.\u00a0pylori<\/jats:italic>, CMV and HSV\u20101 in different vascular locations were as follows: aorta (64.7, 35.3, 11.7 and 11.7 respectively); carotid (27.2, 27.2, 9 and 0 respectively); coronary artery (58.3, 33.3, 16.6 and 8.3 respectively). Combined positivity for <jats:italic>C.\u00a0pneumoniae<\/jats:italic> (<jats:italic>C.\u00a0pneumoniae<\/jats:italic> IgA and RT\u2010PCR for <jats:italic>C.\u00a0pneumoniae<\/jats:italic>) was the highest compared with all other groups. Aorta and coronary artery were more susceptible to these pathogens as compared with carotid artery. Moreover, CAD patients\u2019 characteristics were associated with <jats:italic>C.\u00a0pneumoniae<\/jats:italic> positivity (<jats:italic>C.\u00a0pneumoniae<\/jats:italic> IgA and RT\u2010PCR), suggesting thereby that <jats:italic>C.\u00a0pneumoniae<\/jats:italic> may have caused chronic persistent infection in CAD.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2009.02553.x","type":"journal-article","created":{"date-parts":[[2009,11,17]],"date-time":"2009-11-17T22:02:58Z","timestamp":1258495378000},"page":"905-911","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prevalence of <i>Chlamydophila pneumoniae<\/i> is higher in aorta and coronary artery than in carotid artery of coronary artery disease patients"],"prefix":"10.1111","volume":"117","author":[{"given":"HEM 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