{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T08:11:08Z","timestamp":1698826268188},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,24]],"date-time":"2010-01-24T00:00:00Z","timestamp":1264291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p>Br\u00f8chner AC, Dagn\u00e6s\u2010Hansen F, Toft P. Effect of renal and non\u2010renal ischemia\/reperfusion on cell\u2010mediated immunity in organs and plasma. APMIS 2010; 118: 101\u20137.<\/jats:p><jats:p>Acute renal failure (ARF) is a common morbidity factor among patients in the intensive care unit, reaching an incidence from 3% to 30% depending on the definition of ARF and the population. Although the majority of the patients with ARF are treated with continuous renal replacement therapy, the mortality rate still remains above 50%. The causes of death are primarily extra\u2010renal and include infection, shock, septicemia, and respiratory failure. We wanted to evaluate the cell\u2010mediated inflammatory response of renal ischemia\u2013reperfusion (I\/R) and non\u2010renal I\/R, in blood and in distant organs. In our study, 80 mice were divided into four groups. The following surgeries were performed on the groups compared: bilateral renal I\/R by clamping, unilateral renal ischemia, anesthesia only, and unilateral hind leg I\/R. Half of the animals were killed after 2\u2003h and the other half after 24\u2003h. To assess the inflammatory response, we measured myeloperoxidase (MPO) in the organs, and CD 11b and major histocompatibility complex (MHC) II\u2010positive cells in the blood. Non\u2010renal I\/R elicited the most elevated levels of MPO in extra\u2010renal tissue such as the lungs. There was a trend toward higher MPO levels in the kidney following renal I\/R. All kinds of I\/R induced an upregulation of the adhesion molecule CD 11b and a downregulation of MHC II. Renal and non\u2010renal I\/R induced neutrophil infiltration in distant organs. Renal I\/R does not induce a larger cell\u2010mediated inflammatory response in blood and organs than non\u2010renal I\/R.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2009.02567.x","type":"journal-article","created":{"date-parts":[[2010,1,24]],"date-time":"2010-01-24T13:43:42Z","timestamp":1264340622000},"page":"101-107","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of renal and non\u2010renal ischemia\/reperfusion on cell\u2010mediated immunity in organs and plasma"],"prefix":"10.1111","volume":"118","author":[{"given":"ANNE C.","family":"BR\u00d8CHNER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FREDERIK","family":"DAGN\u00c6S\u2010HANSEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PALLE","family":"TOFT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200209000-00016"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00072.2001"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000199079.64231.C1"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00460.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000064946.94590.46"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/88.3.330"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(96)00138-X"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90666.2008"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200001000-00006"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2005.00764.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.3.F525"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070184"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1994.tb04843.x"},{"key":"e_1_2_5_15_2","first-page":"901","article-title":"Acute renal failure after bilateral nephrectomy is associated with cytokine\u2010mediated pulmonary injury","volume":"74","author":"Hoke T","year":"2008","journal-title":"Kidney Int"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200103270-00016"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc370"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051129"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2002.460413.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)00099-9"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00026.2003"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0463.2009.02567.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0463.2009.02567.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T19:49:25Z","timestamp":1698781765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0463.2009.02567.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,24]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1111\/j.1600-0463.2009.02567.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0463.2009.02567.x","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,24]]},"assertion":[{"value":"2010-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}