{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:57:31Z","timestamp":1777885051723,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,24]],"date-time":"2010-01-24T00:00:00Z","timestamp":1264291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p>Cakir E, Demirag F, Aydin M. Cytopathologic differential diagnosis of small cell carcinoma and poorly differentiated non\u2010small cell carcinoma in bronchial lavage specimens using a regression analysis. APMIS 2010; 118: 150\u201355.<\/jats:p><jats:p>The aim of this study was to determine the most significant cytologic features to differentiate small cell carcinoma (SCC) from poorly differentiated non\u2010small cell carcinoma (NSCC) in bronchial lavage specimens. Bronchial lavage specimens from 35 SCC cases and 63 poorly differentiated NSCC cases were examined and the cytologic parameters reviewed retrospectively. Thirty\u2010five cytologic features considered useful in differential diagnosis were assessed. Statistical analysis indicated that salt and pepper chromatin, small cell size and nuclear molding have more than 90% sensitivity and 70% specificity for SCC cases. Logistic regression analysis demonstrated that the most effective criteria to differentiate SCC from poorly differentiated NSCC are small cell size, salt and pepper chromatin, prominent nucleolus and papilla formation. When these selected variables were used, sensitivity for predicting SCC was 94.3% and specificity 96.8%, and sensitivity for predicting NSCC was 96.8% and specificity 94.3%. There are several cytologic features, which are highly sensitive and specific for distinguishing SCC from NSCC. Nuclear features such as chromatin pattern, and size of the nucleoli and nuclei are more valuable than cytoplasmic features to distinguish between the two.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2009.02575.x","type":"journal-article","created":{"date-parts":[[2010,1,24]],"date-time":"2010-01-24T13:43:42Z","timestamp":1264340622000},"page":"150-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cytopathologic differential diagnosis of small cell carcinoma and poorly differentiated non\u2010small cell carcinoma in bronchial lavage specimens using a regression analysis"],"prefix":"10.1111","volume":"118","author":[{"given":"EBRU","family":"CAKIR","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FUNDA","family":"DEMIRAG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MEHTAP","family":"AYDIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,24]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"711","volume-title":"Basic Pathology","author":"Husain AN","year":"2004"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326507"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2005.apm1130309.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001025)90:5<279::AID-CNCR3>3.0.CO;2-D"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000196342"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02718241"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1309\/8MQG-6XEK-3X9L-A9XU"},{"key":"e_1_2_5_9_2","first-page":"208","volume-title":"The Art and Science of Cytopathology Exfoliative Cytology","author":"De May RM","year":"1996"},{"key":"e_1_2_5_10_2","first-page":"769","volume-title":"Diagnostic Cytology and Its Histopathologic Bases","author":"Koss LG","year":"1992"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2057"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20577"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.44.12.997"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10297"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000196105"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.5858\/2005-129-0619-DSCCFN","article-title":"Distinguishing small cell carcinoma from non\u2010small cell carcinoma of the lung: correlating cytologic features and performance in the college of American pathologists non\u2010gynecologic cytology program","volume":"129","author":"Renshaw AA","year":"2005","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_17_2","first-page":"800","article-title":"Cytomorphology of the variants of small cell carcinoma of the lung","volume":"26","author":"Zaharopoulos P","year":"1982","journal-title":"Acta Cytol"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0339(200101)24:1<58::AID-DC1010>3.0.CO;2-O"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0463.2009.02575.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0463.2009.02575.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T19:49:04Z","timestamp":1698781744000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0463.2009.02575.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,24]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1111\/j.1600-0463.2009.02575.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0463.2009.02575.x","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,24]]},"assertion":[{"value":"2010-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}