{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T16:23:03Z","timestamp":1775924583231,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,7,2]],"date-time":"2010-07-02T00:00:00Z","timestamp":1278028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p>Yrj\u00e4n\u00e4inen H, Hyt\u00f6nen J, Hartiala P, Oksi J, Viljanen MK. Persistence of borrelial DNA in the joints of <jats:italic>Borrelia burgdorferi<\/jats:italic>\u2010infected mice after ceftriaxone treatment. APMIS 2010; 118: 665\u201373.<\/jats:p><jats:p>We have earlier shown that <jats:italic>Borrelia burgdorferi<\/jats:italic>\u2010infected and ceftriaxone\u2010treated mice have viable spirochetes in their body, since immunosuppressive treatment allows <jats:italic>B.\u00a0burgdorferi<\/jats:italic> to be detected by culture. However, the niche of the persisting spirochetes remained unknown. In the present study, we analyzed the tissues of <jats:italic>B.\u00a0burgdorferi<\/jats:italic>\u2010infected and ceftriaxone\u2010treated mice by culture and PCR to reveal the foci of persisting spirochetes. C3H\/HeN mice were infected via intradermal needle injection with <jats:italic>B.\u00a0burgdorferi<\/jats:italic> s.s. N40. The mice were treated as follows: (i) short (5\u2003days) and (ii) long (18\u2003days) course of ceftriaxone at 2\u2003weeks of infection and killed after either 10 or 30\u2003weeks, or (iii) the mice received ceftriaxone for 5\u2003days at 18\u2003weeks of infection and were killed 21\u2003weeks after the treatment. All samples of ceftriaxone\u2010treated mice were culture negative, whereas all untreated controls were culture positive. Importantly, <jats:italic>B.\u00a0burgdorferi<\/jats:italic> DNA was detected in the joints of 30\u2013100% of the treated mice. In conclusion, these results combined with earlier results suggest that the joint or a tissue adjacent to the joint is the niche of persisting <jats:italic>B.\u00a0burgdorferi<\/jats:italic> in ceftriaxone\u2010treated mice.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2010.02615.x","type":"journal-article","created":{"date-parts":[[2010,7,6]],"date-time":"2010-07-06T18:19:23Z","timestamp":1278440363000},"page":"665-673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Persistence of borrelial DNA in the joints of <i>Borrelia burgdorferi<\/i>\u2010infected mice after ceftriaxone 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