{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:20:42Z","timestamp":1791566442645,"version":"4.3.4"},"reference-count":83,"publisher":"Wiley","issue":"6-7","license":[{"start":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T00:00:00Z","timestamp":1276560000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>Lajer CB, von Buchwald C. The role of human papillomavirus in head and neck cancer. APMIS 2010; 118: 510\u2013519.<\/jats:p><jats:p>Over the last 20\u2003years, there has been increasing awareness of a subset of squamous cell carcinomas of the head and neck (HNSCC), i.e. HPV\u2010positive HNSCC. These cancers seem to differ somewhat from HPV\u2010negative HNSCC. Patients with HPV\u2010positive HNSCC tend to be younger and have a lower intake of tobacco and alcohol. Distinct molecular profiles separate them from HPV\u2010negative cancers and show similarities with HPV\u2010positive cervical SCC. There is evidence that HPV\u2010positive HNSCC is a sexually transmitted disease. Patients with HPV\u2010positive HNSCC are often diagnosed at a late stage with large cystic lymph nodes in the neck. HPV\u2010positive HNSCC show an affinity for the oropharynx, especially the tonsils and the base of the tongue, and tend to show low differentiation histopathologically. There is a better prognosis regardless of the treatment regimen for HPV\u2010positive HNSCC compared with HPV\u2010negative HNSCC, and this seems to be related to the immune system. 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