{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:49:11Z","timestamp":1791143351180,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T00:00:00Z","timestamp":1287964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>Kim KH, Do I\u2010G, Kim HS, Chang MH, Kim HS, Jun HJ, Uhm J, Yi SY, Lim DH, Ji SH, Park MJ, Lee J, Park SH, Kwon GY, Lim HY. Excision repair cross\u2010complementation group 1 (ERCC1) expression in advanced urothelial carcinoma patients receiving cisplatin\u2010based chemotherapy. APMIS 2010; 118: 941\u20138.<\/jats:p><jats:p>Cisplatin has been the cornerstone of the chemotherapy regimen for urothelial carcinoma. Excision repair cross\u2010complementation group 1 (ERCC1) is a key component of the platinum\u2010DNA repair machinery responsible for nucleotide excision repair. Recent reports have suggested that ERCC1 is a predictive and prognostic marker in solid cancers treated with platinum\u2010based chemotherapy. We performed this study to determine whether or not immunohistochemical expression of ERCC1 can predict objective tumor response and cancer\u2010specific survival in patients with advanced urothelial carcinoma treated with cisplatin\u2010based chemotherapy. We performed a retrospective analysis of 89 patients with advanced or recurrent urothelial cancer, who had undergone treatment at Samsung Medical Center between May 2001 and August 2007. Pretherapeutic biopsy samples from 89 patients with a known tumor response were available. ERCC1 expression was assessed by immunohistochemistry. Of the 89 patients, ERCC1 expression was positive in 49 patients (55%). The overall response rate after chemotherapy was 68.5% (95% CI 54.8\u201374.8%). Among 61 patients who obtained a response, 27 were negative for ERCC\u20101 expression and 34 were positive (p\u2003=\u20030.61). Median duration of follow\u2010up was 53.7\u2003months (range 14.4\u2013152.3\u2003months). Progression\u2010free survival (PFS) was 10.6\u2003months for ERCC\u20101\u2010negative patients and 8.4\u2003months for ERCC\u20101\u2010positive patients (p\u2003=\u20030.03); the difference in overall survival between patients with ERCC\u20101\u2010negative tumors and ERCC\u20101\u2010positive tumors (p\u2003=\u20030.73) was not statistically significant. Other than ERCC1 expression, there was no independent prognostic factor for PFS. These results suggest a negative contribution by ERCC1expression to PFS in metastatic urothelial carcinoma patients treated with cisplatin\u2010based chemotherapy.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2010.02648.x","type":"journal-article","created":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T14:16:27Z","timestamp":1288016187000},"page":"941-948","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Excision repair cross\u2010complementation group 1 (ERCC1) expression in advanced urothelial carcinoma patients receiving cisplatin\u2010based chemotherapy"],"prefix":"10.1111","volume":"118","author":[{"given":"KYOUNG Ha","family":"KIM","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IN\u2010GU","family":"DO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HYEONG 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