{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T08:41:08Z","timestamp":1698828068093},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T00:00:00Z","timestamp":1283385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>Hallander HO, Lepp T, Ljungman M, Netterlid E, Andersson M. Do we need a booster of Hib vaccine after primary vaccination? A study on anti\u2010Hib seroprevalence in Sweden 5 and 15\u2003years after the introduction of universal Hib vaccination related to notifications of invasive disease. APMIS 2010; 118: 878\u201387.<\/jats:p><jats:p>The prevalence of IgG ELISA antibodies against <jats:italic>Haemophilus influenzae<\/jats:italic> polyribosyl ribitol phosphate (anti\u2010Hib) was studied in two Swedish seroepidemiologic materials. One study was performed in 1997 5\u2003years after the introduction of universal Hib vaccination (N\u2003=\u20033320). Ten years later, a similar study was carried out to analyze the effect of vaccination on anti\u2010Hib prevalence (N\u2003=\u20032383). The median values of anti\u2010Hib concentrations (EU\/mL) were almost identical in the two materials. The antigenic pressure including vaccination, natural infections and possible cross\u2010immunizations was thus assumed to be constant. The joint median was 0.50 EU\/mL (95% confidence interval: 0.46, 0.56). However, there were also indications of reduced exposure to \u2018Hib\u2010antigens\u2019 over a 10\u2010year period. The proportion above the cut\u2010off point for protection, 0.15 EU\/mL, decreased significantly for children aged 2\u201319\u2003years from 78% in 1997 to 74% in 2007 (p\u2003=\u20030.034), and there was a significant increase in values below the minimal level of detection for adults from 17% in 1997 to 20% in 2007 (p\u2003=\u20030.009). In the 2007 material no specific age group could be identified with a lower immune profile than other age groups older than 3\u2003years and there was a significant downward trend of invasive infections caused by Hib according to notification data for the period 1997\u20132008. Therefore, the conclusion is that presently there is no need for a booster dose of Hib vaccine in Sweden after primary vaccination but the situation should be carefully monitored.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2010.02674.x","type":"journal-article","created":{"date-parts":[[2010,9,3]],"date-time":"2010-09-03T18:00:22Z","timestamp":1283536822000},"page":"878-887","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Do we need a booster of Hib vaccine after primary vaccination? 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