{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:10:22Z","timestamp":1791090622988,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T00:00:00Z","timestamp":1318809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>Nassehi D, Dyrbye H, Andresen M, Thomsen C, Juhler M, Laursen H, Broholm H. Vascular endothelial growth factor A protein level and gene expression in intracranial meningiomas with brain edema. APMIS 2011; 119: 831\u201343.<\/jats:p><jats:p>Meningiomas are the second most common primary intracranial tumors in adults. Although meningiomas are mostly benign, more than 50% of patients with meningioma develop peritumoral brain edema (PTBE), which may be fatal because of increased intracranial pressure. Vascular endothelial growth factor (VEGF) is an endothelial cell\u2010specific mitogen and angiogen. VEGF\u2010A protein, which is identical to vascular permeability factor, is a regulator of angiogenesis. In this study, 101 patients with meningiomas, and possible co\u2010factors to PTBE, such as meningioma subtypes and tumor location, were examined. Forty\u2010three patients had primary, solitary, supratentorial meningiomas with PTBE. In these, correlations in PTBE, edema index, VEGF\u2010A protein, VEGF gene expression, capillary length, and tumor water content were investigated. DNA\u2010branched hybridization was used for measuring VEGF gene expression in tissue homogenates prepared from frozen tissue samples. The method for VEGF\u2010A analysis resembled an ELISA assay, but was based on chemiluminescence. The edema index was positively correlated to VEGF\u2010A protein (p\u2003=\u20030.014) and VEGF gene expression (p\u2003&lt;\u20030.05). The capillary length in the meningiomas was positively correlated to the PTBE (p\u2003=\u20030.038). If VEGF is responsible for the formation of PTBE, the edema may be treated with the anti\u2010VEGF drug Bevacizumab (Avastin), which has been shown to reduce PTBE in patients with glioblastoma multiforme.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2011.02764.x","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T12:33:51Z","timestamp":1318854831000},"page":"831-843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Vascular endothelial growth factor A protein level and gene expression in intracranial meningiomas with brain edema"],"prefix":"10.1111","volume":"119","author":[{"given":"DAMOUN","family":"NASSEHI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HENRIK","family":"DYRBYE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MORTEN","family":"ANDRESEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CARSTEN","family":"THOMSEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIANNE","family":"JUHLER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HENNING","family":"LAURSEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HELLE","family":"BROHOLM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,17]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-009-0034-5"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2008.01.010"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-200111000-00003"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003300101025"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199308000-00005"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2004.09.029"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.104.3.382"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2007.06.001"},{"key":"e_1_2_7_10_2","first-page":"1029","article-title":"Vascular permeability factor\/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis","volume":"146","author":"Dvorak HF","year":"1995","journal-title":"Am J Pathol"},{"key":"e_1_2_7_11_2","first-page":"673","article-title":"Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing","volume":"57","author":"Dvorak HF","year":"1987","journal-title":"Lab Invest"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0958-1669(00)00153-1"},{"key":"e_1_2_7_13_2","first-page":"344","article-title":"Expression of vascular endothelial growth factor in human meningiomas and peritumoral brain areas","volume":"38","author":"Ding YS","year":"2008","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-004-9164-4"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-008-9559-8"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/MI\/2006\/36376"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200004000-00033"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.12.047"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.028647"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199407000-00001"},{"key":"e_1_2_7_21_2","first-page":"111","article-title":"Regulation of vascular endothelial growth factor secretion in human meningioma cells","volume":"98","author":"Tsai JC","year":"1999","journal-title":"J Formos Med Assoc"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/1087057105277414"},{"key":"e_1_2_7_23_2","first-page":"163","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"Perry A","year":"2007"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021186401522"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1988.tb00954.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199208000-00002"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199706000-00029"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21022"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-195750"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-008-9573-x"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-9801-z"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0463.2011.02764.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0463.2011.02764.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T19:07:49Z","timestamp":1697396869000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0463.2011.02764.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,17]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1111\/j.1600-0463.2011.02764.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0463.2011.02764.x","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,17]]},"assertion":[{"value":"2011-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}