{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:00:14Z","timestamp":1791115214146,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T00:00:00Z","timestamp":1334102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Fismen S, Ingvarsson G, Moseng D, Dufour ND, J\u00f8rgensen L. A clinical\u2010pathological review of hidradenitis suppurativa: Using immunohistochemistry one disease becomes two. APMIS 2012; 120: 433\u201340.<\/jats:p><jats:p>We report the results of a re\u2010examination of a series of 57 biopsies from 50 patients with the clinical diagnosis of hidradenitis suppurativa, submitted to the Department of Pathology at the University Hospital of Northern Norway, Troms\u00f8, Norway. The biopsy material came from hospitals and physicians all over northern Norway in the years 2000\u20132007. All tissue material was resectioned and stained with the immunohistochemical reagent, cytokeratin (AE1\/AE3\/PKC26), and that made it possible to divide the material into two different disease categories: (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#b1\">1<\/jats:ext-link>) 36 biopsies from 30 cases had tissue inflammation after rupture of keratin\u2010rich epidermal cysts, which we call \u2018horny cell inflammation\u2019, followed by extensive cutaneous thrombi and infarcts, and (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#b2\">2<\/jats:ext-link>) 21 biopsies from 20 cases had \u2018apocrinitis\u2019 defined here as an inflammatory destruction of apocrine skin glands, and partly of close eccrine glands. The two disease populations differed: the patients with a diagnosis of horny cell inflammation were younger and mainly women; those with a diagnosis of apocrinitis, as defined here, were older, men and women equally represented.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2011.02771.x","type":"journal-article","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T00:25:12Z","timestamp":1334190312000},"page":"433-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A clinical\u2010pathological review of hidradenitis suppurativa: using immunohistochemistry one disease becomes two"],"prefix":"10.1111","volume":"120","author":[{"given":"SILJE","family":"FISMEN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GISLI","family":"INGVARSSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAGFINN","family":"MOSENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DEIRDRE","family":"NATHALIE DUFOUR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LEIF","family":"J\u00d8RGENSEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,11]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"91","volume-title":"Dictionnaire de M\u00e9decine, un R\u00e9petoire G\u00e9n\u00e9ral des Sciences Medicales sous la Rapport Th\u00e9orique et Practique. 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