{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T07:10:39Z","timestamp":1781334639575,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T00:00:00Z","timestamp":1324252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Lindemann PC, Risberg K, Wiker HG, Mylvaganam H. Aminoglycoside resistance in clinical <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Klebsiella pneumoniae<\/jats:italic> isolates from Western Norway. APMIS 2012; 120: 495\u2013502.<\/jats:p><jats:p>Resistance to gentamicin in <jats:italic>Escherichia coli<\/jats:italic> from blood culture has shown an increase over the past decade in Norway. This study was done to investigate aminoglycoside resistance in <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Klebsiella pneumoniae<\/jats:italic> in Western Norway. The material included 49 blood culture isolates which had shown aminoglycoside resistance collected during 2000\u20132009. To investigate co\u2010resistance to alternative antibiotics and dynamics involved in aminoglycoside resistance 67 isolates (mostly from urine) exhibiting resistance to both aminoglycosides and extended spectrum beta\u2010lactam antibiotics were also included. MIC values were obtained for amikacin, gentamicin, kanamycin, netilmicin, streptomycin and tobramycin and all isolates were screened using PCR for <jats:italic>aac(3)\u2010II<\/jats:italic> and <jats:italic>aac(6\u2032)\u2010Ib<\/jats:italic>, encoding aminoglycoside modifying enzymes. Resistance to \u22653 aminoglycosides was found in 92% of the isolates and 60.3% showed resistance to gentamicin, netilmicin, tobramycin and kanamycin. Amikacin resistance was low. Co\u2010resistance to ciprofloxacin was found in 88% of the isolates with gentamicin resistance. <jats:italic>aac(3)\u2010IIa\/c<\/jats:italic> was found in 79.3% and <jats:italic>aac(6\u2032)\u2010Ib<\/jats:italic> in 37.9% of the isolates and 28.4% harboured both genes. <jats:italic>aac(6\u2032)\u2010Ib\u2010cr<\/jats:italic>, possibly contributing to ciprofloxacin resistance was found mostly in extended spectrum beta\u2010lactamase producers. The aminoglycoside resistance patterns indicate co\u2010existence of multiple resistance mechanisms. The use of ciprofloxacin and third generation cephalosporins is likely to have contributed to the increase in aminoglycoside resistance in Norway.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2011.02856.x","type":"journal-article","created":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T09:07:39Z","timestamp":1324285659000},"page":"495-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Aminoglycoside resistance in clinical <i>Escherichia<\/i> coli and <i>Klebsiella pneumoniae<\/i> isolates from Western Norway"],"prefix":"10.1111","volume":"120","author":[{"given":"PAUL CHRISTOFFER","family":"LINDEMANN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KINE","family":"RISBERG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HARALD G.","family":"WIKER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HAIMA","family":"MYLVAGANAM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,19]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"Antibiotic guide from The Western Norway Regional Health Authority.2010; Available online:http:\/\/antibiotika.ihelse.net. 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