{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:53:42Z","timestamp":1762271622836},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T00:00:00Z","timestamp":1337040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>The human sequential organ failure assessment (<jats:styled-content style=\"fixed-case\">SOFA<\/jats:styled-content>) scoring system is used worldwide in intensive care units for assessing the extent of organ dysfunction\/failure in patients with severe sepsis. An increasing number of septic cases are caused by Gram\u2010positive bacteria as <jats:italic>Staphylococcus aureus<\/jats:italic>. The aim of the current study was to apply the human <jats:styled-content style=\"fixed-case\">SOFA<\/jats:styled-content> parameters in an awake, porcine model of severe <jats:italic>S. aureus<\/jats:italic> sepsis. Five pigs were inoculated intravenously with <jats:italic>S. aureus<\/jats:italic> and two control animals were sham\u2010inoculated. Extensive clinical monitoring and sequential blood sampling was obtained and analysed for <jats:styled-content style=\"fixed-case\">SOFA<\/jats:styled-content> parameters. Dysfunction\/failure was observed in the respiratory, haemostatic and hepatic system of all infected animals, together with initial cardiovascular dysfunction. The pulmonary system was the first to fail clinically, which corresponds with similar human findings, whereas the liver was affected earlier in pigs compared to humans. The use of human <jats:styled-content style=\"fixed-case\">SOFA<\/jats:styled-content> parameters was valuable in identifying dysfunctional\/failing organs and showed consistency between this porcine model and human severe sepsis. Applying <jats:styled-content style=\"fixed-case\">SOFA<\/jats:styled-content> parameters in this model increased the relevance for comparison to clinical methods of evaluating human severe sepsis. Changes in <jats:styled-content style=\"fixed-case\">SOFA<\/jats:styled-content> parameters may in future porcine studies serve as a target for monitoring the effect of therapeutic intervention.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2012.02917.x","type":"journal-article","created":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T12:28:59Z","timestamp":1337084939000},"page":"909-921","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The use of sequential organ failure assessment parameters in an awake porcine model of severe <i>Staphylococcus aureus<\/i> sepsis"],"prefix":"10.1111","volume":"120","author":[{"given":"Karen E.","family":"Soerensen","sequence":"first","affiliation":[{"name":"Department of Veterinary Disease Biology Faculty of Life Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole L.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Disease Biology Faculty of Life Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malene M.","family":"Birck","sequence":"additional","affiliation":[{"name":"Department of Veterinary Disease Biology Faculty of Life Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorte B.","family":"Soerensen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Disease Biology Faculty of Life Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e1ll S.","family":"Leifsson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Disease Biology Faculty of Life Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik E.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Disease Biology Faculty of Life Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bent","family":"Aalbaek","sequence":"additional","affiliation":[{"name":"Department of Veterinary Disease Biology Faculty of Life Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemarie T.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Faculty of Life Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wiinberg","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Faculty of Life Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mads","family":"Kjelgaard\u2010Hansen","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Faculty of Life Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M. H.","family":"Heegaard","sequence":"additional","affiliation":[{"name":"Innate Immunology Group Division of Veterinary Diagnostics and Research National Veterinary Institute Technical University of Denmark Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tine M.","family":"Iburg","sequence":"additional","affiliation":[{"name":"Department of Veterinary Disease Biology Faculty of Life Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Pathology and Wildlife Disease National Veterinary Institute Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022139"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1644"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000050454.01978.3B"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.14.1754"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709751"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-2121-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000182798.39709.84"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050931"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199811000-00016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000191337.01036.b7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2001.01632.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000419328"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199908000-00039"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70082-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000194725.48928.3A"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68853-3"},{"key":"e_1_2_7_18_1","first-page":"1","article-title":"Comparative anatomy and physiology of the pig","volume":"25","author":"Swindle MM","year":"1998","journal-title":"Scand J Lab Anim Sci"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2010.02042.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0147-51-14"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1258\/la.2010.009100"},{"key":"e_1_2_7_22_1","volume-title":"Theory and Practice of Histlogical Techniques","author":"Bancroft J","year":"2008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2005.tb00066.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-0491(97)00362-3"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2009.02.002"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2008.02122.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31819c37be"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.10.023"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/315692"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(00)00189-4"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-198103000-00004"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00010.2008"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2005.05.015"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-370491-7.00013-1"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2356"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-370491-7.00016-7"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198604000-00002"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0463.2012.02917.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0463.2012.02917.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T04:58:02Z","timestamp":1700542682000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0463.2012.02917.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,15]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1600-0463.2012.02917.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0463.2012.02917.x","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,15]]},"assertion":[{"value":"2011-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-04-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}