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Immunohistochemical analysis of cortactin and fascin\u20101 was performed in 50 pancreatic and 40 ampulla of Vater adenocarcinomas. The specimens were from 29 R0, 8 R1, and 13 palliative resections of pancreatic adenocarcinomas and 18 R0, 14 R1, and 8 palliative resections of ampulla of Vater adenocarcinomas. \u2018R0\u2019 resection is defined by complete removal of the tumor and histologically negative surgical margins and \u2018R1\u2019 resection indicates the presence of microscopically residual disease at the surgical margins. The level of expression was assessed by scoring the intensity of cytoplasmic or membranous immunostaining on a 4\u2010point scale. Higher immunostaining scores of cortactin and fascin\u20101 were both significantly correlated with histological grade, American Joint Committee on Cancer (<jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content>) stage, and survival rate in all patients. In conclusion, overexpression of cortactin and fascin\u20101 implies poorer tumor differentiation, advanced <jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content> stage, and shorter survival rate in pancreatic and ampulla of Vater adenocarcinomas.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2012.02952.x","type":"journal-article","created":{"date-parts":[[2012,8,13]],"date-time":"2012-08-13T07:03:12Z","timestamp":1344841392000},"page":"171-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The correlation of cortactin and fascin\u20101 expression with clinicopathological parameters in pancreatic and ampulla of Vater adenocarcinoma"],"prefix":"10.1111","volume":"121","author":[{"given":"Wen\u2010Chiuan","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Pathology Tri\u2010Service General Hospital National Defense Medical Center Taichung county 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