{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:50:29Z","timestamp":1720227029479},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T00:00:00Z","timestamp":1346976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Using a nonlethal systemic <jats:italic>Aspergillus fumigatus<\/jats:italic> infection, we have recently shown that similarly efficient elimination of fungus from spleens of prototypic Th1 (C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6) and prototypic Th2 (<jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c) mice is associated with differential immune responses. In light of these data and given the disseminated character of infection, the aim of the present study is to explore whether there are also strain\u2010dependent differences in antifungal responses in peripheral tissues of infected mice. Although similar efficiency of conidia removal was noted in liver and kidneys of both strains, <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c mice seemed more prone to tissue injury. Compared with other nonlymphoid organs, lungs proved immunologically the most responsive in systemic aspergillosis. Lower numbers of neutrophils and macrophages in the lungs of infected <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c mice, delayed and lower (compared with C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice) expression of their oxidative activity, along with late <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 and upregulated <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 production by lung cells might be responsible for slower elimination of <jats:italic>A. fumigatus<\/jats:italic> from the lungs of this mouse strain. The data obtained imply that lungs should be viewed as mandatory organ in evaluation of immune\u2010mediated antifungal potential of drugs in models of systemic\/disseminated infection and that strain differences noted in tissue responses should be taken into account in these settings.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2012.02958.x","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T13:26:53Z","timestamp":1347024413000},"page":"211-220","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Differential strain\u2010related tissue immune response to sublethal systemic <i>Aspergillus fumigatus<\/i> infection in mice"],"prefix":"10.1111","volume":"121","author":[{"given":"Ivana","family":"Mirkov","sequence":"first","affiliation":[{"name":"Department of Ecology Institute for Biological Research \u2018Sinisa Stankovic\u2019 University of Belgrade Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmina","family":"Glamoclija","sequence":"additional","affiliation":[{"name":"Department of Plant Physiology (Mycology Lab.) 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