{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:25:00Z","timestamp":1770956700961,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T00:00:00Z","timestamp":1344384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Burkitt lymphoma (<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>) accounts for 80% of Non\u2010Hodgkin lymphoma in Uganda. The tumour is fast growing with a very short doubling time. Inhibition of apoptosis, achieved through the apoptosis inhibitor family of proteins enhances survival of cancer cells. The aim of this study was to explore the expression of apoptosis related proteins Survivin, Livin and Thrombospondin\u20101 (<jats:styled-content style=\"fixed-case\">TSP<\/jats:styled-content>\u20101) in <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> and comparing it with the expression in reactive follicular hyperplasia. Among the <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> cases, survivin was positive in 37 (75%) and negative in 12 (25%). Livin staining was positive in 23 (48%) and negative in 25 (52%) of the <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> cases. <jats:styled-content style=\"fixed-case\">TSP<\/jats:styled-content>\u20101 was positive in 40 (87%) and negative in 6 (13%) of the <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> cases. All the 10 reactive lymphoid hyperplasia (<jats:styled-content style=\"fixed-case\">RLH<\/jats:styled-content>) were positive for survivin, livin expression was found in 4 (40%), whereas <jats:styled-content style=\"fixed-case\">TSP<\/jats:styled-content>\u20101 was positive in 7 (70%) of the <jats:styled-content style=\"fixed-case\">RLH<\/jats:styled-content> cases. Among the <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>, there was no statistically significant association between survivin and livin expression (p\u00a0=\u00a00.6), livin and <jats:styled-content style=\"fixed-case\">TSP<\/jats:styled-content>\u20101 (p\u00a0=\u00a01.0) or survivin and <jats:styled-content style=\"fixed-case\">TSP<\/jats:styled-content>\u20101 (p\u00a0=\u00a00.6). Likewise no statistical association was found between the expressions of the proteins in <jats:styled-content style=\"fixed-case\">RLH<\/jats:styled-content>. There was no statistically significant difference between the expression frequency of the apoptosis associated proteins examined in <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RLH<\/jats:styled-content>. In conclusion, we have demonstrated the expression of inhibitor of apoptosis proteins, survivin and Livin and the pro\u2010apoptotic protein <jats:styled-content style=\"fixed-case\">TSP<\/jats:styled-content>\u20101 in endemic <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>. No significant difference was found between <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RLH<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2012.02962.x","type":"journal-article","created":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T12:17:24Z","timestamp":1344428244000},"page":"239-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Expression of apoptosis associated proteins <scp>S<\/scp>urvivin, <scp>L<\/scp>ivin and <scp>T<\/scp>hrombospondin\u20101 in <scp>B<\/scp>urkitt lymphoma"],"prefix":"10.1111","volume":"121","author":[{"given":"Sam","family":"Kalungi","sequence":"first","affiliation":[{"name":"Section for Pathology The Gade Institute University of Bergen Bergen Norway"},{"name":"Department of Pathology Makerere University College of Health Sciences Kampala 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