{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T03:01:52Z","timestamp":1775358112349,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,8,13]],"date-time":"2012-08-13T00:00:00Z","timestamp":1344816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2013,4]]},"abstract":"Positive coeliac serology with normal villous morphology (NVM<\/jats:styled-content>) indicates potential coeliac disease (CD<\/jats:styled-content>). Few studies have compared characteristics of NVM<\/jats:styled-content> vs villous atrophy in patients with positive serology. Our aim was to determine the independent clinical predictors of NVM<\/jats:styled-content> in children with positive CD<\/jats:styled-content> serology. We performed a structured medical record review of patients aged 1\u201319\u00a0years who presented for an initial CD<\/jats:styled-content> evaluation between 2000 and 2010 at a large teaching hospital. Data collection included demographics, medical history, prior history of gluten avoidance, CD<\/jats:styled-content>\u2010specific serology, oesophagogastroduodenoscopy and histopathology. Predictors of NVM<\/jats:styled-content> (vs Marsh III) were determined using multivariable logistic regression. Among 320 patients with positive serology, we identified 62 patients (19%, 95% CI 15\u201324) with NVM<\/jats:styled-content> (i.e. potential CD<\/jats:styled-content>). Younger children may have been more likely to exhibit NVM<\/jats:styled-content> (p\u00a0=\u00a00.06). Three significant predictors of NVM<\/jats:styled-content> were prior gluten avoidance (OR<\/jats:styled-content> 4.17, 95% CI 1.02\u201317.13), positive tissue transglutaminase antibody but <100\u00a0U\/mL (OR<\/jats:styled-content> 14.75, 95% CI 3.33\u201365.30), and absence of gross duodenal abnormalities (OR 3.48, 95% CI 1.51\u20138.03). Among children with positive CD<\/jats:styled-content> serology, prior gluten avoidance predicts NVM<\/jats:styled-content>. Future studies are warranted on the impact of gluten intake and CD<\/jats:styled-content> testing in children without prior established CD<\/jats:styled-content> diagnosis.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2012.02966.x","type":"journal-article","created":{"date-parts":[[2012,8,13]],"date-time":"2012-08-13T07:01:07Z","timestamp":1344841267000},"page":"266-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Characteristics of children with positive coeliac serology and normal villous morphology: potential coeliac disease"],"prefix":"10.1111","volume":"121","author":[{"given":"Pornthep","family":"Tanpowpong","sequence":"first","affiliation":[{"name":"Department of Pediatrics Harvard Medical School Massachusetts General Hospital for Children Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarabeth","family":"Broder\u2010Fingert","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Harvard Medical School Massachusetts General Hospital for Children Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aubrey J.","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Harvard Medical School Massachusetts General Hospital for Children Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Carlos A.","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Harvard Medical School Massachusetts General Hospital Boston MA 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