{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T01:46:31Z","timestamp":1777254391657,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,8,19]],"date-time":"2005-08-19T00:00:00Z","timestamp":1124409600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives: <\/jats:bold> The objective of this pilot study was to investigate the feasibility of periodontal ligament (PDL) generation on an implant surface by approximating a tooth\u2010to\u2010implant contact using orthodontics.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Maxillary second premolars of six beagle dogs were extracted bilaterally. After 2 weeks of healing, hydroxyapatite (HA) coated titanium implants, 5\u2003mm in length and 3.3\u2003mm in diameter, were placed in the extraction sites. One side of the arch was used as control. Orthodontic tooth movement was initiated following implant placement to tip the first premolar roots into contact with the implant. This was achieved in 4\u20136 weeks as confirmed radiographically. Tooth\u2010to\u2010implant contact was maintained for further 6 weeks after which time, teeth were separated from implant contact orthodontically. After further 2 weeks of stabilization, the animals were sacrificed. Samples were analyzed by Faxitron radiographs before histology. Histology samples were prepared with Stevenel's Blue and Van Gieson stain and were subjected to polarized light microscopy.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Histologic analysis revealed transfer and formation of PDL\u2010like structure with formation of cellular cementum on the implant surfaces, in four out of six animals, where tooth\u2010to\u2010implant contact had been achieved. Direct bone\u2010to\u2010implant contact was noted in the areas coronal to the PDL\u2010like tissue, an important sign to distinguish between PDL\u2010like tissue and connective tissue that could originate from the coronal portion of a failing implant. Additionally, at the site of contact, the implant surface revealed some resorption of the HA coating.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> An animal model was established in which the proximity of tooth\u2010to\u2010implant contact lead to partial generation of PDL on a bioactive implant surface in four out of six animals.<\/jats:p>","DOI":"10.1111\/j.1600-0501.2005.01152.x","type":"journal-article","created":{"date-parts":[[2005,8,19]],"date-time":"2005-08-19T14:29:48Z","timestamp":1124461788000},"page":"396-401","source":"Crossref","is-referenced-by-count":26,"title":["Partial generation of periodontal ligament on endosseous dental implants in dogs"],"prefix":"10.1111","volume":"16","author":[{"given":"Leila","family":"Jahangiri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramin","family":"Hessamfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.9.597"},{"key":"e_1_2_7_3_1","first-page":"193","article-title":"Periodontal ligament formation around titanium implants using cultured periodontal ligament cells","volume":"15","author":"Choi B.H.","year":"2000","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(19991215)47:4<585::AID-JBM16>3.0.CO;2-O"},{"key":"e_1_2_7_5_1","first-page":"55","article-title":"Mandibular implants and the growing patient","volume":"9","author":"Cronin R.J.","year":"1994","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0011-8532(22)00602-4","article-title":"Implant use in growing patients. 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