{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:19:41Z","timestamp":1791188381614,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,2]],"date-time":"2006-03-02T00:00:00Z","timestamp":1141257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To investigate the significance of the initial stability of dental implants for the establishment of osseointegration in an experimental capsule model for bone augmentation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Material and methods:<\/jats:bold>\n                    Sixteen male rats were used in the study. In each rat, muscle\u2010periosteal flaps were elevated on the lateral aspect of the mandibular ramus on both sides, resulting in exposure of the bone surface. Small perforations were then produced in the ramus. A rigid, hemispherical Teflon\n                    <jats:sup>\u00ae<\/jats:sup>\n                    capsule with a diameter of 6\u2003mm and a height of 4\u2003mm and with a hole in its middle portion, prepared to fit the circumference of an ITI\n                    <jats:sup>\u00ae<\/jats:sup>\n                    HC titanium implant of 2.8\u2003mm in diameter, was fixed to the ramus using 4 mini\u2010screws. On one side of the jaw, the implant was placed through the hole in such a way that its apex did not make contact with the mandibular ramus (test). This placement of the implant did not ensure primary stability. On the other side of the jaw, a similar implant was placed through the hole of the capsule in such a way that contact was made between the implant and the surface of the ramus (control). This provided primary stability of the implant. After placement of the implants, the soft tissues were repositioned over the capsules and sutured. After 1, 3, 6 and 9 months, four animals were sacrificed and subjected to histometric analysis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The mean height of direct bone\u2010to\u2010implant contact of implants with primary stability was 38.8%, 52.9%, 64.6% and 81.3% of the implant length at 1, 3, 6 and 9 months, respectively. Of the bone adjacent to the implant surface, 28.1%, 28.9%, 52.6% and 69.6%, respectively, consisted of mineralized bone. At the test implants, no bone\u2010to\u2010implant contact was observed at any observation time or in any of these non\u2010stabilized specimens.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The findings of the present study indicate that primary implant stability is a prerequisite for successful osseointegration, and that implant instability results in fibrous encapsulation, thus confirming previously made clinical observations.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0501.2005.01201.x","type":"journal-article","created":{"date-parts":[[2006,3,2]],"date-time":"2006-03-02T11:01:47Z","timestamp":1141297307000},"page":"244-250","source":"Crossref","is-referenced-by-count":274,"title":["Significance of primary stability for osseointegration of dental implants"],"prefix":"10.1111","volume":"17","author":[{"given":"Natalia","family":"Lioubavina\u2010Hack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklaus P.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorkild","family":"Karring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,2]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"233","article-title":"Reconstruction of severely resorbed edentulous maxillae using osseointegrated fixtures in immediate autogenous bone grafts","volume":"5","author":"Adell R.","year":"1990","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(86)80010-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1993.040205.x"},{"key":"e_1_2_6_5_1","first-page":"377","article-title":"Guided tissue regeneration for implants placed into extraction sockets and for implant dehiscences","volume":"10","author":"Becker W.","year":"1990","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_6_6_1","first-page":"305","article-title":"The effect of clinical loading on bone regeneration by GTAM barriers","volume":"9","author":"Becker W.","year":"1994","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_7_1","first-page":"43","volume-title":"Non Cemented Total Hip Arthroplasty","author":"Brunski J.B.","year":"1988"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1990.010104.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199804)40:1<1::AID-JBM1>3.0.CO;2-Q"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1993.040406.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1991.020401.x"},{"key":"e_1_2_6_12_1","first-page":"19","article-title":"Generation of new bone around titanium implants using a membrane technique","volume":"4","author":"Dahlin C.","year":"1989","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130208.x"},{"key":"e_1_2_6_14_1","first-page":"204","article-title":"Immediate occlusal loading of Branemark implants applied in various jawbone regions","volume":"3","author":"Glauser R.","year":"2001","journal-title":"Clinical Oral Implants Research"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1991.020403.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.012001009.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.070105.x"},{"key":"e_1_2_6_18_1","first-page":"474","article-title":"Treatment of peri\u2010implantitis using guided bone regeneration and bone grafts alone or in combination in beagle dogs. 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