{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:19:29Z","timestamp":1792606769407,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives: <\/jats:bold> The aim of this prospective study was to evaluate dimensional alterations of the peri\u2010implant tissues at single\u2010tooth restorations from the time of implant placement to 1\u2010year post\u2010loading.<\/jats:p><jats:p><jats:bold>Material and methods: <\/jats:bold> Eleven patients, aged 18\u201336 years, subjected to single\u2010tooth replacements with implant\u2010supported restorations (Br\u00e5nemark implant<jats:sup>\u00ae<\/jats:sup> system) in the maxillary anterior region were included in the analysis. The implant installation was performed as a two\u2010stage procedure with a 6\u2010month healing interval. Bone dimensions were determined by direct assessments immediately following implant placement and at abutment connection. The prosthetic restoration was placed approximately 1 month after abutment surgery. Radiographic and clinical examinations were performed at crown placement and at 1\u2010year post\u2010loading. Assessments of the soft tissues at the implant site and at the neighboring teeth were performed before and during implant placement, before abutment connection, after crown placement and at the 1\u2010year follow\u2010up examination. Mean values and standard deviations were calculated for each variable and interval, with the subject as the statistical unit.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> At the time of abutment connection, a mean loss of bone height at the facial and lingual aspect of the implant amounting to 0.7\u20131.3\u2003mm (<jats:italic>P<\/jats:italic>&lt;0.05) was recorded, whereas no significant change was noted at proximal sites. A mean reduction of 0.4\u2003mm of the labial bone thickness was observed between implant placement and the second\u2010stage surgery. The radiographic bone\u2010to\u2010implant level showed a mean loss of 0.9\u2003mm between abutment connection and crown placement (<jats:italic>P<\/jats:italic>&lt;0.05) and a further 0.7\u2003mm loss at 1 year (<jats:italic>P<\/jats:italic>&lt;0.05). The thickness of the labial mucosa was increased at crown placement followed by a slight remission at 1 year. During the corresponding interval, a mean apical displacement of the labial soft tissue margin of 0.6\u2003mm had taken place (<jats:italic>P<\/jats:italic>&lt;0.05). A papilla fill of \u226550% was observed at a frequency of 32% at crown placement and 86% at 1 year.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> The results demonstrated that following implant surgery remodeling takes place, which is manifested in diminished bone dimensions, both horizontally and vertically, at the facial aspect of the implant. The observed soft tissue alterations after the crown placement may affect the esthetic appeal of the restorative therapy.<\/jats:p>","DOI":"10.1111\/j.1600-0501.2005.01210.x","type":"journal-article","created":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T15:02:18Z","timestamp":1141830138000},"page":"165-171","source":"Crossref","is-referenced-by-count":237,"title":["Tissue alterations at implant\u2010supported single\u2010tooth replacements: a 1\u2010year prospective clinical study"],"prefix":"10.1111","volume":"17","author":[{"given":"Giuseppe","family":"Cardaropoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Lekholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan 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