{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:16:58Z","timestamp":1790731018008,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,6,6]],"date-time":"2006-06-06T00:00:00Z","timestamp":1149552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2006,8]]},"abstract":"Abstract<\/jats:title>\n \n Objectives:<\/jats:bold>\n To assess the microbiological outcome of local administration of minocycline hydrochloride microspheres 1\u2003mg (Arestin\n \u00ae<\/jats:sup>\n ) in cases with peri\u2010implantitis and with a follow\u2010up period of 12 months.\n <\/jats:p>\n \n Material and methods:<\/jats:bold>\n After debridement, and local administration of chlorhexidine gel, peri\u2010implantitis cases were treated with local administration of minocycline microspheres (Arestin\n \u00ae<\/jats:sup>\n ). The DNA\u2013DNA checkerboard hybridization method was used to detect bacterial presence during the first 360 days of therapy.\n <\/jats:p>\n \n Results:<\/jats:bold>\n At Day 10, lower bacterial loads for 6\/40 individual bacteria including\n Actinomyces gerensceriae<\/jats:italic>\n (\n P<\/jats:italic>\n <0.1),\n Actinomyces israelii<\/jats:italic>\n (\n P<\/jats:italic>\n <0.01),\n Actinomyces naeslundi<\/jats:italic>\n type 1 (\n P<\/jats:italic>\n <0.01) and type 2 (\n P<\/jats:italic>\n <0.03),\n Actinomyces odontolyticus<\/jats:italic>\n (\n P<\/jats:italic>\n <0.01),\n Porphyromonas gingivalis<\/jats:italic>\n (\n P<\/jats:italic>\n <0.01) and\n Treponema socranskii<\/jats:italic>\n (\n P<\/jats:italic>\n <0.01) were found. At Day 360 only the levels of\n Actinobacillus actinomycetemcomitans<\/jats:italic>\n were lower than at baseline (mean difference: 1 \u00d7 10\n 5<\/jats:sup>\n ; SE difference: 0.34 \u00d7 10\n 5<\/jats:sup>\n , 95% CI: 0.2 \u00d7 10\n 5<\/jats:sup>\n to 1.2 \u00d7 10\n 5<\/jats:sup>\n ;\n P<\/jats:italic>\n <0.03). Six implants were lost between Days 90 and 270. The microbiota was successfully controlled in 48%, and with definitive failures (implant loss and major increase in bacterial levels) in 32% of subjects.\n <\/jats:p>\n \n Conclusions:<\/jats:bold>\n At study endpoint, the impact of Arestin\n \u00ae<\/jats:sup>\n on\n A. actinomycetemcomitans<\/jats:italic>\n was greater than the impact on other pathogens. Up to Day 180 reductions in levels of\n Tannerella forsythia<\/jats:italic>\n ,\n P. gingivalis<\/jats:italic>\n , and\n Treponema denticola<\/jats:italic>\n were also found. Failures in treatment could not be associated with the presence of specific pathogens or by the total bacterial load at baseline. Statistical power analysis suggested that a case control study would require approximately 200 subjects.\n <\/jats:p>","DOI":"10.1111\/j.1600-0501.2006.01269.x","type":"journal-article","created":{"date-parts":[[2006,6,6]],"date-time":"2006-06-06T04:52:57Z","timestamp":1149569577000},"page":"386-393","source":"Crossref","is-referenced-by-count":101,"title":["Antimicrobial therapy using a local drug delivery system (Arestin\n \u00ae<\/sup>\n ) in the treatment of peri\u2010implantitis. I: microbiological outcomes"],"prefix":"10.1111","volume":"17","author":[{"given":"G. Rutger","family":"Persson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni E.","family":"Salvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J. A.","family":"Heitz\u2010Mayfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklaus P.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2004.06.005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00720.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400312"},{"key":"e_1_2_6_5_1","volume-title":"Statistical Methods for Rates and Proportions","author":"Fleiss J.L.","year":"1981"},{"key":"e_1_2_6_6_1","first-page":"829","article-title":"Microbiota around root\u2010form endosseous implants","volume":"17","author":"Heydenrijk K.","year":"2002","journal-title":"International Journal of Oral & Maxillofacial 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