{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:03:37Z","timestamp":1787015017401,"version":"build-2736575974"},"reference-count":102,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,7,26]],"date-time":"2007-07-26T00:00:00Z","timestamp":1185408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To assess the impact of overloading on peri\u2010implant bone level and the bone\u2010to\u2010implant contact (BIC) in the presence of healthy or inflamed peri\u2010implant tissues.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and methods:<\/jats:bold>\n                    Four screw\u2010shaped machined implants were placed bilaterally in the mandible of four beagle dogs and left submerged for 3 months. Prosthetic abutments were connected either in supra\u2010occlusal contact with the opposite teeth (overloaded) or in infra\u2010occlusal position (unloaded). In each dog, cotton floss ligatures were placed unilaterally around abutments to promote plaque accumulation; the contralateral side was brushed three times a week. There were four experimental sites, two implants in each: loaded uninflamed (LU), loaded inflamed (LI), unloaded uninflamed (UU), and unloaded inflamed (UI). Clinical and radiographic parameters were recorded at baseline and every 3 months throughout the observation period. At 12 months, the dogs were sacrificed and histomorphometric analysis was performed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Implants with ligature\u2010induced peri\u2010implantitis presented high inflammatory indices throughout the observation period. Clinical parameters did not change from baseline for both LU and UU. Loading significantly increased the percentage of BIC (BIC%) (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05) and slightly increased crestal bone resorption, but not apical to the implant neck. Both LI and UI groups showed significant peri\u2010implant bone loss (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01), mostly horizontal on the buccal aspect and angular on the lingual aspect, which exposed implant threads. Loading significantly (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05) increased implant thread exposure due to buccal and lingual vertical bone resorption.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    In the presence of uninflamed peri\u2010implant mucosa, overloading of implants in the dog model increased BIC% and slightly reduced marginal bone level. However, resorption did not progress beyond the implant neck. Overloading aggravated the plaque\u2010induced bone resorption when peri\u2010implant inflammation was present.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0501.2007.01374.x","type":"journal-article","created":{"date-parts":[[2007,7,27]],"date-time":"2007-07-27T09:10:19Z","timestamp":1185527419000},"page":"601-610","source":"Crossref","is-referenced-by-count":132,"title":["Impact of implant overloading on the peri\u2010implant bone in inflamed and non\u2010inflamed peri\u2010implant mucosa"],"prefix":"10.1111","volume":"18","author":[{"given":"Avital","family":"Kozlovsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim","family":"Tal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben\u2010Zion","family":"Laufer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Leshem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Rohrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miron","family":"Weinreb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zvi","family":"Artzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,26]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Tissue\u2010Integrated Prostheses; Osseointegration in Clinical Dentistry","author":"Adell R.","year":"1987"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(81)80077-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(98)70211-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1994.050303.x"},{"key":"e_1_2_7_6_1","first-page":"215","article-title":"Adaptive bone remodeling around oral implants under axial and nonaxial loading conditions in the dog mandible","volume":"12","author":"Barbier L.","year":"1997","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_7_1","first-page":"31","article-title":"Clinical and microbiologic findings that may contribute to dental implant failure","volume":"5","author":"Becker W.","year":"1990","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00747.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb00520.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1991.020206.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1992.030101.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008505-199200140-00011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1980.tb01958.x"},{"key":"e_1_2_7_14_1","first-page":"15","article-title":"Biomaterials and biomechanics of oral and maxillofacial implants","volume":"15","author":"Bunski J.B.","year":"2000","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(16)31195-8"},{"key":"e_1_2_7_16_1","first-page":"380","article-title":"The relationship of some histologic parameters, radiographic evaluations, and periotest measurements of oral implants","volume":"12","author":"Caulier H.","year":"1997","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.2.186"},{"key":"e_1_2_7_18_1","first-page":"91","article-title":"The longitudinal clinical efficacy of osseointegrated dental implants","volume":"2","author":"Cox J.F.","year":"1987","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1982.tb00172.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.012003207.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1992.030301.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1982.tb02111.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1997.080502.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/00003086-198511000-00027","article-title":"The pathomechanics of osteoporoses","volume":"200","author":"Frost H.M.","year":"1985","journal-title":"Clinical Orthopedics and Related Research"},{"key":"e_1_2_7_25_1","first-page":"175","article-title":"Wolff's law and bone's structural adaptations to mechanical usage","volume":"64","author":"Frost H.M.","year":"1994","journal-title":"Angle Orthodontist"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1965.36.2.141"},{"key":"e_1_2_7_27_1","first-page":"393","article-title":"The combined effect of inflammation and trauma of occlusion to periodontitis","volume":"19","author":"Glickman I.","year":"1969","journal-title":"International Dental Journal"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.012001001.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.012003196.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.120602.x"},{"key":"e_1_2_7_31_1","first-page":"144","article-title":"Bone reactions at implants subjected to experimental peri\u2010implantitis and static load","volume":"29","author":"Gotfredsen K.","year":"2002","journal-title":"Clinical Oral Implants Research"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.070204.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.1.59"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01019.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.9.1412"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.11.1117"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.9.548"},{"key":"e_1_2_7_38_1","first-page":"104","article-title":"Influence of bone quality on stress distribution for endosseous implants","volume":"23","author":"Holmes D.C.","year":"1997","journal-title":"Journal of Oral Implantology"},{"key":"e_1_2_7_39_1","first-page":"345","article-title":"Mechanical loading of Br\u00e5nemark implants affects interfacial bone modeling and remodeling","volume":"9","author":"Hoshaw S.J.","year":"1994","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.3.396"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.070208.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.1997.tb00001.x"},{"key":"e_1_2_7_43_1","first-page":"377","article-title":"Mobility assessment with the Periotest system in relation to histologic findings of oral implants","volume":"13","author":"Isidor F.","year":"1998","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_44_1","first-page":"211","article-title":"Osseointegrated implants in the treatment of partially edentulous patients","volume":"4","author":"Jemt T.","year":"1989","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_45_1","first-page":"112","article-title":"A formaldehyde glutaraldehyde fixative of high osmolarity for use in electron microscopy","volume":"3","author":"Karnovsky M.J.","year":"1965","journal-title":"Journal of Cell Biology"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01067.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01022.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2004.01413.x"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1993.040101.x"},{"key":"e_1_2_7_50_1","first-page":"374","article-title":"ITI titanium plasma\u2010sprayed screw implants in the treatment of edentulous mandibles","volume":"10","author":"Leimola\u2010Virtanen R.","year":"1995","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1992.030303.x"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1992.030102.x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1974.tb01234.x"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.070405.x"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(88)90109-6"},{"key":"e_1_2_7_56_1","first-page":"3","article-title":"A modified gingival index for use in clinical trials","volume":"8","author":"Lobene R.R.","year":"1986","journal-title":"Clinical Preventive Dentistry"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb00180.x"},{"key":"e_1_2_7_58_1","first-page":"839","article-title":"Experimental peri\u2010implant tissue breakdown around different dental implant surfaces","volume":"19","author":"Martins M.C.","year":"2004","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.8.1367"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(93)90185-O"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.012002144.x"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.id.0000165033.34294.db"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.id.0000148556.73137.24"},{"key":"e_1_2_7_64_1","first-page":"677","article-title":"The influence of controlled occlusal overload on peri\u2010implant tissue","volume":"13","author":"Miyata T.","year":"1998","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_65_1","first-page":"425","article-title":"The influence of controlled occlusal overload on peri\u2010implant tissue. Part 3","volume":"15","author":"Miyata T.","year":"2000","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_66_1","first-page":"384","article-title":"The influence of controlled occlusal overload on peri\u2010implant tissue. Part 4","volume":"17","author":"Miyata T.","year":"2002","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.2329\/perio.39.234"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1994.tb00007.x"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1987.tb00298.x"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092420203"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(92)90557-Q"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(94)90441-3"},{"key":"e_1_2_7_73_1","first-page":"390","article-title":"Periotest method as a measure of osseointegrated oral implant stability","volume":"5","author":"Olive J.","year":"1990","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1976.tb00082.x"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1994.050409.x"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1990.010102.x"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1992.030302.x"},{"key":"e_1_2_7_78_1","first-page":"326","article-title":"Bending overload and implant fracture","volume":"10","author":"Ranger B.","year":"1995","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(90)90325-7"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1991.020306.x"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1966.tb01860.x"},{"key":"e_1_2_7_82_1","first-page":"92","article-title":"Failures in the osseo\u2010integration of endosseous implants","volume":"8","author":"Salonen M.A.","year":"1993","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1991.020305.x"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1992.030401.x"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.6.529"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130201.x"},{"key":"e_1_2_7_87_1","first-page":"383","article-title":"Microbiologic and radiographic analysis of ligature\u2010induced peri\u2010implantitis with different dental implant surfaces","volume":"18","author":"Shibli J.A.","year":"2003","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2000.5.1.119"},{"key":"e_1_2_7_89_1","first-page":"269","article-title":"Experimental tooth hypermobility in dog","volume":"24","author":"Svanberg G.","year":"1973","journal-title":"Odontologisk Revy"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1984.55.10.604"},{"key":"e_1_2_7_91_1","first-page":"55","article-title":"Periotest","volume":"6","author":"Teerlinck J.","year":"1991","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_92_1","first-page":"74","article-title":"Correlation between mucosal inflammation and marginal bone loss around hydroxyapatite\u2010coated implants","volume":"12","author":"Teixeira E.R.","year":"1997","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820190802"},{"key":"e_1_2_7_94_1","first-page":"611","article-title":"Evaluation of three different dental implants in ligature\u2010induced peri\u2010implantitis in the beagle dog. Part I. Clinical evaluation","volume":"12","author":"Tillmanns H.W.","year":"1997","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_95_1","first-page":"59","article-title":"Evaluation of three different dental implants in ligature\u2010induced peri\u2010implantitis in the beagle dog. Part II. Histology and microbiology","volume":"13","author":"Tillmanns H.W.","year":"1998","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.090606.x"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374990130010201"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1995.060104.x"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008505-199904000-00012"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1979.tb02185.x"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1979.50.7.355"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.070102.x"},{"key":"e_1_2_7_103_1","first-page":"19","article-title":"The biomechanics of force distribution in implant\u2010supported prosthesis","volume":"8","author":"Weinberg L.A.","year":"1993","journal-title":"International Journal of Oral & Maxillofacial Implants"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0501.2007.01374.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0501.2007.01374.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T03:32:23Z","timestamp":1697427143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0501.2007.01374.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,26]]},"references-count":102,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1111\/j.1600-0501.2007.01374.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0501.2007.01374.x","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,26]]}}}