{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:10:08Z","timestamp":1792656608643,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,3,12]],"date-time":"2007-03-12T00:00:00Z","timestamp":1173657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim: <\/jats:bold> To monitor over 12 months clinical and radiographic changes occurring after adjunctive local delivery of minocycline microspheres for the treatment of peri\u2010implantitis.<\/jats:p><jats:p><jats:bold>Material and methods: <\/jats:bold> In 25 partially edentulous subjects, 31 implants diagnosed with peri\u2010implantitis were treated. Three weeks after oral hygiene instruction, mechanical debridement and local antiseptic cleansing using 0.2% chlorhexidine gel, baseline (Day 0) parameters were recorded. Minocycline microspheres (Arestin<jats:sup>\u00ae<\/jats:sup>) were locally delivered to each implant site with bone loss and a probing pocket depth (PPD) \u22655\u2003mm. Rescue therapy with Arestin<jats:sup>\u00ae<\/jats:sup> was allowed at Days 180 and 270 at any site exhibiting an increase in PPD\u22652\u2003mm from the previous visit. The following clinical parameters were recorded at four sites\/implant at Day 0, 10, 30, 60, 90, 180, 270 and 360: PPD, clinical attachment level (CAL), bleeding on probing (BOP) and plaque index (PlI).<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Six implants in six subjects were either rescued or exited because of persisting active peri\u2010implantitis. Successful implants showed a statistically significant reduction in both PPD and percentage of sites with BOP between baseline and Day 360 (<jats:italic>P<\/jats:italic>&lt;0.05). At mesial implant sites, the mean PPD reduction amounted to 1.6\u2003mm (95% CI: 0.9\u20132.2\u2003mm, <jats:italic>P<\/jats:italic>&lt;0.001) and was accompanied by a statistically significant reduction of the BOP value (<jats:italic>P<\/jats:italic>&lt;0.001). Binary regression analysis showed that the clinical parameters and smoking history could not discriminate between successfully treated and rescued or exited implants at any observation time point.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> Non\u2010surgical mechanical treatment of peri\u2010implantitis lesions with adjunctive local delivery of microencapsulated minocycline led to positive effects on clinical parameters up to 12 months.<\/jats:p>","DOI":"10.1111\/j.1600-0501.2007.01377.x","type":"journal-article","created":{"date-parts":[[2007,3,12]],"date-time":"2007-03-12T13:44:43Z","timestamp":1173707083000},"page":"281-285","source":"Crossref","is-referenced-by-count":95,"title":["Adjunctive local antibiotic therapy in the treatment of peri\u2010implantitis II: clinical and radiographic outcomes"],"prefix":"10.1111","volume":"18","author":[{"given":"Giovanni E.","family":"Salvi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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