{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:55:33Z","timestamp":1767970533728,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T00:00:00Z","timestamp":1206489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim: <\/jats:bold> The aim of this study was to test the hypothesis that recombinant human growth and differentiation factor\u20105 (rhGDF\u20105) enhances bone formation in sinus floor augmentations in miniature pigs.<\/jats:p><jats:p><jats:bold>Material and methods: <\/jats:bold> The maxillary sinus floors in 12 adult female Goettingen minipigs were augmented with \u03b2\u2010tricalcium phosphate (\u03b2\u2010TCP) on one side. The contralateral test side was augmented using two concentrations of rhGDF\u20105 (400\u2003\u03bcg rhGDF\u20105\/g \u03b2\u2010TCP; 800\u2003\u03bcg rhGDF\u20105\/g \u03b2\u2010TCP) delivered on \u03b2\u2010TCP (six animals each). One dental implant was inserted into each sinus floor augmentation. After 4 and 12 weeks, histological and histomorphometric assessment of non\u2010decalcified histological specimens was performed.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> The results showed significantly higher mean values of volume density (VD) of newly formed bone using the concentration of 400\u2003\u03bcg\/g \u03b2\u2010TCP (22.8%) compared with the respective control (8%) after 4 weeks (<jats:italic>P<\/jats:italic>=0.05).<\/jats:p><jats:p>The bone\u2010to\u2010implant contact rates were also significantly enhanced after 4 weeks between test sites (400\u2003\u03bcg: 41.9%; 800\u2003\u03bcg: 40.6%) and control sites (400\u2003\u03bcg: 7.8%; 800\u2003\u03bcg: 16.4%) (400\u2003\u03bcg: <jats:italic>P<\/jats:italic>=0.024; 800\u2003\u03bcg: <jats:italic>P<\/jats:italic>=0.048).<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> It is concluded that rhGDF\u20105 delivered on \u03b2\u2010TCP significantly enhanced early bone formation compared with \u03b2\u2010TCP alone in sinus lift procedures in miniature pigs.<\/jats:p>","DOI":"10.1111\/j.1600-0501.2007.01494.x","type":"journal-article","created":{"date-parts":[[2008,3,27]],"date-time":"2008-03-27T05:40:27Z","timestamp":1206596427000},"page":"522-529","source":"Crossref","is-referenced-by-count":38,"title":["Sinus floor augmentation with recombinant human growth and differentiation factor\u20105 (rhGDF\u20105): a histological and histomorphometric study in the Goettingen miniature pig"],"prefix":"10.1111","volume":"19","author":[{"given":"Rudolf 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