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The authors discuss the metabolic perturbations seen in insulin\u2010resistant myocardium and how they result in structural and other biochemical changes that ultimately result in left ventricular hypertrophy and diastolic and systolic dysfunction. The authors also discuss the utility of metabolic imaging to study metabolic derangement as seen in insulin\u2010resistant rodents. The role of positron emission tomography and cine\u2010magnetic resonance imaging coregistration in quantifying myocardial glucose uptake is demonstrated in fasted, 13\u2010week old Sprague\u2010Dawley rats under insulin\u2010\/glucose\u2010stimulated conditions. 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