{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:03:45Z","timestamp":1787015025765,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,9,15]],"date-time":"2008-09-15T00:00:00Z","timestamp":1221436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    Effective carrier technologies and dosing appear critical for the successful use of bone morphogenetic proteins (BMPs). This study evaluated radiographically the potential of a purpose\u2010designed titanium porous\u2010oxide implant surface combined with recombinant human BMP\u20102 (rhBMP\u20102) to stimulate alveolar ridge augmentation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Material and methods:<\/jats:bold>\n                    Twelve young\u2010adult Labrador dogs were used. Three 10\u2010mm titanium implants per jaw quadrant were placed 5\u2003mm into the alveolar ridge following extraction of the premolar teeth and reduction of alveolar ridge. Six animals received implants coated with rhBMP\u20102 at 0.75 or 1.5\u2003mg\/ml randomized to contralateral jaw quadrants. Another six animals received implants coated with rhBMP\u20102 at 3\u2003mg\/ml or uncoated control using the same split\u2010mouth design. The mucoperiosteal flaps were advanced, adapted, and sutured to submerge the implants. Radiographic registrations were made immediately postsurgery (baseline), and at weeks 4 and 8 (end of study).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    rhBMP\u20102\u2010coated implants exhibited robust radiographic bone formation extending to and above the implant platform from week 4 (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01). Some rhBMP\u20102\u2010coated implants showed voids within the newly formed bone that gradually resolved and\/or implant displacement, being severe in two animals receiving implants coated with rhBMP\u20102 at 3\u2003mg\/ml. Controls showed limited, if any, new bone formation at weeks 4 and 8 postsurgery. There were no significant differences among the rhBMP\u20102 groups in bone gain.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The titanium porous\u2010oxide surface serves as an effective carrier for rhBMP\u20102, showing a clinically significant potential to stimulate local bone formation. With the carrier technology used, therapeutic dosage appears to be in the range of 0.75\u20131.5\u2003mg\/ml.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0501.2008.01567.x","type":"journal-article","created":{"date-parts":[[2008,9,15]],"date-time":"2008-09-15T05:06:32Z","timestamp":1221455192000},"page":"1027-1033","source":"Crossref","is-referenced-by-count":78,"title":["Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein\u20102: radiographic observations"],"prefix":"10.1111","volume":"19","author":[{"given":"Knut N.","family":"Leknes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Qahash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Polimeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Susin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf M. E.","family":"Wikesj\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,9,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453679608995598"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1242\/jcs.102.2.341","article-title":"Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures","volume":"102","author":"Beresford J.N.","year":"1992","journal-title":"Journal of Cellular Science"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.08.018"},{"key":"e_1_2_6_5_1","volume-title":"Guided Bone Regeneration in Implant Dentistry","author":"Buser D.","year":"1994"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.24.9843"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.8.1241"},{"key":"e_1_2_6_8_1","first-page":"739","article-title":"Radiographic analysis of regenerated bone around endosseous implants in canine using recombinant human bone morphogenetic protein\u20102","volume":"12","author":"Cochran D.L.","year":"1997","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199406000-00006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041540215"},{"key":"e_1_2_6_11_1","first-page":"659","article-title":"Improved retention and bone\u2010to\u2010implant contact with fluoride\u2010modified titanium implants","volume":"19","author":"Ellingsen J.E.","year":"2004","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240580312"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01064.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.12.1186"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0905-7161.2003.clr140617.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/2532051"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00324.x"},{"key":"e_1_2_6_18_1","first-page":"313","article-title":"Bone grafts and biomaterials used as bone grafts substitutes","author":"Ouhayoun J\u2010P.","year":"1997","journal-title":"Proceedings of the 2nd European Workshop on Periodontology: Chemicals in Periodontics"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1002\/j.1460-2075.1990.tb07376.x","article-title":"OP\u20101 cDNA encodes an osteogenic protein in the TGF\u2010\u03b2 family","volume":"9","author":"\u00d6zkaynak E.","year":"1990","journal-title":"The EMBO Journal"},{"issue":"1","key":"e_1_2_6_20_1","first-page":"116","article-title":"Bone induction by BMPs\/OPs and related family members in primates. 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