{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:32:56Z","timestamp":1768314776046,"version":"3.49.0"},"reference-count":59,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T00:00:00Z","timestamp":1215648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives: <\/jats:bold> To evaluate the effects of maxillary sinus floor elevation by a tissue\u2010engineered bone complex with OsteoBone<jats:sup>\u2122<\/jats:sup> and bone marrow stromal cells (bMSCs) in rabbits.<\/jats:p><jats:p><jats:bold>Material and methods: <\/jats:bold> Autologous bMSCs from adult New Zealand rabbits were cultured and combined with OsteoBone<jats:sup>\u2122<\/jats:sup> at a concentration of 20 \u00d7 10<jats:sup>6<\/jats:sup>\u2003cells\/ml <jats:italic>in vitro<\/jats:italic>. Twenty\u2010four animals were used and randomly allocated into groups. For each time point, 16 maxillary sinus floor elevation surgeries were made bilaterally in eight animals and randomly repaired by bMSCs\/material (i.e. OsteoBone<jats:sup>\u2122<\/jats:sup>), material, autogenous bone and blood clot (<jats:italic>n<\/jats:italic>=4 per group). A polychrome sequential fluorescent labeling was also performed post\u2010operatively. The animals were sacrificed 2, 4 and 8 weeks after the procedure and evaluated histologically as well as histomorphometrically.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> New bone area significantly decreased from weeks 2 to 8 in the blood clot group, while bone area in the autologous bone reduced from weeks 4 to 8. In both groups, a significant amount of fatty tissue appeared at week 8. Accordingly, augmented height in both groups was also significantly decreased from weeks 2 to 8. The bone area in the material\u2010alone group as well as in the bMSCs\/material group, on the other hand, increased over time. Significantly more newly formed bone area and mineralization was observed in the center of the raised space in the bMSCs\/material group than in the material\u2010alone group. The augmented height was maintained in these two groups throughout the course of this study.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> These results suggest that OsteoBone<jats:sup>\u2122<\/jats:sup> can successfully be used as a bone graft substitute and that the combination of this material with bMSCs can effectively promote new bone formation in sinus elevation.<\/jats:p>","DOI":"10.1111\/j.1600-0501.2008.01577.x","type":"journal-article","created":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T11:30:53Z","timestamp":1215689453000},"page":"804-813","source":"Crossref","is-referenced-by-count":55,"title":["Maxillary sinus floor elevation using a tissue\u2010engineered bone complex with OsteoBone<sup>\u2122<\/sup> and bMSCs in rabbits"],"prefix":"10.1111","volume":"19","author":[{"given":"X.\u2010Juan","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.\u2010Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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