{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:20:40Z","timestamp":1767990040408,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,12,10]],"date-time":"2008-12-10T00:00:00Z","timestamp":1228867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim: <\/jats:bold> The aim of this study was to test the hypothesis that recombinant human growth and differentiation factor\u20105 (rhGDF\u20105) in combination with a \u03b2\u2010tricalcium phosphate (\u03b2\u2010TCP) scaffold material results in superior bone formation in sinus floor augmentations in miniature pigs compared with a particulated autogenous bone graft combined with the scaffold material.<\/jats:p><jats:p><jats:bold>Material and methods: <\/jats:bold> Six adult female Goettingen minipigs underwent a maxillary sinus floor augmentation procedure. In a split\u2010mouth design, the sinus floors were augmented with \u03b2\u2010TCP mixed with autogenous cortical bone chips, in a ratio of approximately 1\u2003:\u20031, on one side. The contralateral test site was augmented using \u03b2\u2010TCP coated with two concentrations of rhGDF\u20105 (400\u2003\u03bcg rhGDF\u20105\/g \u03b2\u2010TCP or 800\u2003\u03bcg rhGDF\u20105\/g \u03b2\u2010TCP; three animals in each case). Simultaneously, one dental implant was inserted into each sinus floor augmentation. After 12 weeks, a histological and histomorphometric assessment of non\u2010decalcified histological specimens was made.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> There were significantly higher mean values of volume density of newly formed bone using \u03b2\u2010TCP coated with two concentrations of rhGDF\u20105 (400\u2003\u03bcg: 32.9%; 800\u2003\u03bcg: 23.9%) than with the corresponding control (autogenous bone\/\u03b2\u2010TCP) (14.6%, 12.9%) (<jats:italic>P<\/jats:italic>=0.012, <jats:italic>P<\/jats:italic>=0.049). The bone\u2010to\u2010implant contact rates (BIC) were significantly enhanced in test sites (400\u2003\u03bcg: 84.2%; 800\u2003\u03bcg: 69.8%) compared with the corresponding control sites (24.8%, 40.8%) (<jats:italic>P<\/jats:italic>=.027, <jats:italic>P<\/jats:italic>=.045).<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> rhGDF\u20105 delivered on \u03b2\u2010TCP significantly enhanced bone formation compared with \u03b2\u2010TCP combined with autogenous bone in sinus lift procedures in miniature pigs.<\/jats:p>","DOI":"10.1111\/j.1600-0501.2008.01628.x","type":"journal-article","created":{"date-parts":[[2008,12,10]],"date-time":"2008-12-10T15:27:00Z","timestamp":1228922820000},"page":"175-182","source":"Crossref","is-referenced-by-count":41,"title":["Sinus floor augmentation with recombinant human growth and differentiation factor\u20105 (rhGDF\u20105): a pilot study in the Goettingen miniature pig comparing autogenous bone and rhGDF\u20105"],"prefix":"10.1111","volume":"20","author":[{"given":"Rudolf Matthias","family":"Gruber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arwed","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Albert","family":"Merten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Pippig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz\u2010Josef","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Schliephake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,21]]},"reference":[{"issue":"2","key":"e_1_2_6_2_1","first-page":"S96","article-title":"Osteoinduction, osteoconduction and osseointegration","volume":"10","author":"Albrektsson T.","year":"2001","journal-title":"European Spine Journal"},{"key":"e_1_2_6_3_1","first-page":"613","article-title":"Grafting of the maxillary sinus floor with autogenous marrow and bone","volume":"38","author":"Boyne P.J.","year":"1980","journal-title":"Journal of Oral Surgery"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.08.018"},{"issue":"1","key":"e_1_2_6_5_1","first-page":"S23","article-title":"Growth\/differentiation factor\u20105 (gdf\u20105) and skeletal development","volume":"83","author":"Buxton P.","year":"2001","journal-title":"The Journal of Bone and Joint Surgery"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"28227","DOI":"10.1016\/S0021-9258(18)46918-9","article-title":"Cartilage\u2010derived morphogenetic proteins. 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