{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:50:07Z","timestamp":1791399007771,"version":"4.3.3"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,21]],"date-time":"2009-01-21T00:00:00Z","timestamp":1232496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    The use of barrier membranes in guided bone regeneration (GBR) procedures for the treatment of alveolar bone defects is common practice. The objective of this study was to test whether a synthetic bioresorbable polyethylene glycol (PEG) hydrogel membrane could result in a similar amount of vertical bone fill as a standard collagen membrane, both combined with a membrane supporting material.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Material and methods:<\/jats:bold>\n                    The study enrolled 37 patients requiring implant treatment with an expected osseous defect in the posterior maxilla or mandible. After raising a mucoperiosteal flap, the implant sites were prepared and dental implants placed. The defect height was then measured and defects &lt;3\u2003mm were excluded from the study. Defects were grafted with bovine bone mineral and randomly covered with either a collagen membrane (control group, 18 patients) or a PEG hydrogel membrane (test group, 19 patients), which is applied as a liquid. After a healing period of 6 months, surgical re\u2010entry was performed and the change in vertical bone height from baseline evaluated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Well\u2010vascularized hard tissue was apparent at all sites and the regenerated bone was similar to the surrounding native bone. Mean vertical defect fill after 6 months was 5.63\u00b11.84\u2003mm at test sites and 4.25\u00b11.16\u2003mm at control sites, and the mean defect fills were 94.9% and 96.4% at test and control sites, respectively. More soft tissue complications were observed with the PEG membrane (e.g., delayed or incomplete wound healing) but all sites recovered uneventfully.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The new PEG hydrogel membrane was as successful as a standard collagen membrane in the treatment of bony dehiscence defects around dental implants with simplified clinical handling.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0501.2008.01634.x","type":"journal-article","created":{"date-parts":[[2009,1,15]],"date-time":"2009-01-15T07:35:26Z","timestamp":1232004926000},"page":"162-168","source":"Crossref","is-referenced-by-count":120,"title":["A randomized, controlled clinical trial to evaluate a new membrane for guided bone regeneration around dental implants"],"prefix":"10.1111","volume":"20","author":[{"given":"Ronald E.","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian A.","family":"H\u00e4lg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Thoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph H. F.","family":"H\u00e4mmerle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130603.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb00901.x"},{"key":"e_1_2_6_4_1","first-page":"522","article-title":"Successful bone formation at immediate transmucosal implants","volume":"13","author":"H\u00e4mmerle C.H.","year":"1998","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.012001009.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01342.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.00921.x"},{"key":"e_1_2_6_8_1","first-page":"258","article-title":"Bone regeneration using a synthetic matrix containing a PTH peptide combined with a grafting material","volume":"22","author":"Jung R.E.","year":"2007","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01228.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt818"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-3804(05)60258-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.12.046"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01100.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1994.tb00011.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008505-200009010-00011"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1600-0501.2008.01604.x","article-title":"Evaluation of a new biodegradable membrane to prevent gingival ingrowth into mandibular bone defects in minipigs","volume":"20","author":"Thoma D.S.","journal-title":"Clinical Oral Implants Research"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1997.84"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31477"},{"key":"e_1_2_6_19_1","first-page":"844","article-title":"Resorbable versus nonresorbable membranes in combination with Bio\u2010Oss for guided bone regeneration","volume":"12","author":"Zitzmann N.U.","year":"1997","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_20_1","first-page":"355","article-title":"Long\u2010term results of implants treated with guided bone regeneration","volume":"16","author":"Zitzmann N.U.","year":"2001","journal-title":"International Journal of Oral & Maxillofacial Implants"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0501.2008.01634.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0501.2008.01634.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T18:39:06Z","timestamp":1697049546000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0501.2008.01634.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,21]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1111\/j.1600-0501.2008.01634.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0501.2008.01634.x","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,21]]}}}