{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T11:57:28Z","timestamp":1793793448259,"version":"4.6.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,3,11]],"date-time":"2009-03-11T00:00:00Z","timestamp":1236729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    The aim of the present randomized\u2010controlled double\u2010blinded clinical multicenter study was to assess the use of either a new cross\u2010linked (VN) or a native collagen membrane (BG) for the treatment of dehiscence\u2010type defects at titanium implants.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Material and methods:<\/jats:bold>\n                    A total of\n                    <jats:italic>n<\/jats:italic>\n                    =54 patients were recruited in four German university clinics. According to a parallel\u2010groups design, dehiscence\u2010type defects at titanium implants were filled with a natural bone mineral and randomly assigned to either VN or BG. Submerged sites were allowed to heal for 4 months. Primary (e.g., changes in defect length \u2013\u0394DL, quality of newly formed tissue [0\u20134] \u2013 TQ) and secondary parameters (e.g., membrane exposure, tissue conditions at dehisced sites) were consecutively recorded.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Four patients were excluded due to an early wound infection (VN:3; BG:1), and one patient was lost during follow\u2010up (VN). The mean \u0394DL was 3.0 \u00b1 2.5\u2003mm in the VN, and 1.94 \u00b1 2.13\u2003mm in the BG group. The assessment of TQ revealed comparable mean values in both groups (VN: 3.05 \u00b1 1.66, BG: 3.46 \u00b1 1.48). A significant correlation between membrane exposure and inflammation of the adjacent soft tissue was observed in the VN group. In both groups, the mean DL and TQ values were not significantly different at either non\u2010exposed or exposed implant sites.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The results of the present study have indicated that VN supported bone regeneration on a level non\u2010inferior to BG. However, in case of a premature membrane exposure, cross\u2010linking might impair soft\u2010tissue healing or may even cause wound infections.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0501.2008.01689.x","type":"journal-article","created":{"date-parts":[[2009,3,11]],"date-time":"2009-03-11T07:29:39Z","timestamp":1236756579000},"page":"742-749","source":"Crossref","is-referenced-by-count":82,"title":["Use of a new cross\u2010linked collagen membrane for the treatment of dehiscence\u2010type defects at titanium implants: a prospective, randomized\u2010controlled double\u2010blinded clinical multicenter study"],"prefix":"10.1111","volume":"20","author":[{"given":"J\u00fcrgen","family":"Becker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Al\u2010Nawas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus 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