{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:36:29Z","timestamp":1793208989460,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,5,9]],"date-time":"2010-05-09T00:00:00Z","timestamp":1273363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives: <\/jats:bold> The aim of the present study was to histologically evaluate and compare a new prototype collagen type I\/III\u2010containing equine\u2010 (EB) and a bovine\u2010 (BB) derived cancellous bone block in a dog model.<\/jats:p><jats:p><jats:bold>Materials and methods: <\/jats:bold> Four standardized box\u2010shaped defects were bilaterally created at the buccal aspect of the alveolar ridge in the lower jaws of five beagle dogs and randomly allocated to either EB or BB. Each experimental site was covered by a native (non\u2010crosslinked) collagen membrane and left to heal in a submerged position for 12 weeks. Dissected blocks were processed for semi\u2010\/and quantitative analyses.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Both groups had no adverse clinical or histopathological events (i.e. inflammatory\/foreign body reactions). BB specimens revealed no signs of biodegradation and were commonly embedded in a fibrous connective tissue. New bone formation and bony graft integration were minimal. In contrast, EB specimens were characterized by a significantly increased cell (i.e. osteoclasts and multinucleated giant cells)\u2010mediated degradation of the graft material (<jats:italic>P<\/jats:italic>&lt;0.001). The amount and extent of bone ingrowth was consistently higher in all EB specimens, but failed to reach statistical significance in comparison with the BB group (<jats:italic>P<\/jats:italic>&gt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> It was concluded that the application of EB may not be associated with an improved bone formation than BB.<\/jats:p><jats:p> <jats:bold>To cite this article:<\/jats:bold>\n          \u2028Schwarz F, Ferrari D, Balic E, Buser D, Becker J, Sager M. Lateral ridge augmentation using equine\u2010 and bovine\u2010derived cancellous bone blocks: a feasibility study in dogs.\u2028<jats:italic>Clin. Oral Impl. Res<\/jats:italic>. <jats:bold>21<\/jats:bold>, 2010; 904\u2013912.\u2028doi: 10.1111\/j.1600\u20100501.2010.01951.x<\/jats:p>","DOI":"10.1111\/j.1600-0501.2010.01951.x","type":"journal-article","created":{"date-parts":[[2010,5,10]],"date-time":"2010-05-10T01:38:28Z","timestamp":1273455508000},"page":"904-912","source":"Crossref","is-referenced-by-count":60,"title":["Lateral ridge augmentation using equine\u2010 and bovine\u2010derived cancellous bone blocks: a feasibility study in dogs"],"prefix":"10.1111","volume":"21","author":[{"given":"Frank","family":"Schwarz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ela","family":"Balic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Buser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Sager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.120612.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.291213.x"},{"key":"e_1_2_6_4_1","first-page":"29","article-title":"Localized ridge augmentation using guided bone regeneration. 1. 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