{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T16:52:44Z","timestamp":1794329564836,"version":"4.9.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T00:00:00Z","timestamp":1312243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            <jats:bold>Objective: <\/jats:bold> To monitor clinical, microbiological and host\u2010derived alterations occurring around teeth and titanium implants during the development of experimental gingivitis\/mucositis and their respective healing sequence in humans.<\/jats:p><jats:p>\n            <jats:bold>Material and methods: <\/jats:bold> Fifteen subjects with healthy or treated periodontal conditions and restored with dental implants underwent an experimental 3\u2010week period of undisturbed plaque accumulation in the mandible. Subsequently, a 3\u2010week period with optimal plaque control was instituted. At Days 0, 7, 14, 21, 28, 35 and 42, the presence\/absence of plaque deposits around teeth and implants was assessed, (plaque index [PlI]) and the gingival\/mucosal conditions were evaluated (gingival index[GI]). Subgingival\/submucosal plaque samples and gingival\/mucosal crevicular fluid (CF) samples were collected from two pre\u2010determined sites around each experimental unit. CF samples were analyzed for matrix\u2010metalloproteinase\u20108 (MMP\u20108) and interleukin\u20101beta (IL\u20101\u03b2). Microbial samples were analyzed using DNA\u2013DNA hybridization for 40 species.<\/jats:p><jats:p>\n            <jats:bold>Results: <\/jats:bold> During 3 weeks of plaque accumulation, the median PlI and GI increased significantly at implants and teeth. Implant sites yielded a greater increase in the median GI compared with tooth sites. Over the 6\u2010week experimental period, the CF levels of MMP\u20108 were statistically significantly higher at implants compared with teeth (<jats:italic>P<\/jats:italic>&lt;0.05). The CF IL\u20101\u03b2 levels did not differ statistically significantly between teeth and implants (<jats:italic>P<\/jats:italic>&gt;0.05). No differences in the total DNA counts between implant and tooth sites were found at any time points. No differences in the detection frequency were found for putative periodontal pathogens between implant and tooth sites.<\/jats:p><jats:p>\n            <jats:bold>Conclusion: <\/jats:bold> Peri\u2010implant soft tissues developed a stronger inflammatory response to experimental plaque accumulation when compared with that of their gingival counterparts. Experimental gingivitis and peri\u2010implant mucositis were reversible at the biomarker level. Clinically, however, 3 weeks of resumed plaque control did not yield pre\u2010experimental levels of gingival and peri\u2010implant mucosal health indicating that longer healing periods are needed.<\/jats:p><jats:p>\n            <jats:bold>To cite this article:<\/jats:bold>\u2028Salvi GE, Aglietta M, Eick S, Sculean A, Lang NP &amp; Ramseier CA. Reversibility of experimental peri\u2010implant mucositis compared with experimental gingivitis in humans.\u2028<jats:italic>Clin. Oral Impl. Res<\/jats:italic>. <jats:bold>23<\/jats:bold>, 2012; 182\u2013190. \u2028doi: 10.1111\/j.1600\u20100501.2011.02220.x<\/jats:p>","DOI":"10.1111\/j.1600-0501.2011.02220.x","type":"journal-article","created":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T09:50:23Z","timestamp":1312278623000},"page":"182-190","source":"Crossref","is-referenced-by-count":305,"title":["Reversibility of experimental peri\u2010implant mucositis compared with experimental gingivitis in humans"],"prefix":"10.1111","volume":"23","author":[{"given":"Giovanni 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