{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:53:51Z","timestamp":1793055231032,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,14]],"date-time":"2011-11-14T00:00:00Z","timestamp":1321228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      The aim of this controlled randomized clinical trial was to evaluate the efficacy of a xenogeneic collagen matrix (\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      ) to augment the keratinized tissue around implants supporting prosthetic restorations at 6\u00a0months when compared with the standard treatment, the connective tissue autograft,\n                      <jats:styled-content style=\"fixed-case\">CTG<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>This randomized longitudinal parallel controlled clinical trial studied 24 patients with at least one location with minimal keratinized tissue (\u22641\u00a0mm).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measure<\/jats:title>\n                    <jats:p>The 6\u2010month width of keratinized tissue. As secondary outcomes the esthetic outlook, the maintenance of peri\u2010implant mucosal health and the patient morbidity were assessed pre\u2010operatively and 1, 3, and 6\u00a0months post\u2010operatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 6\u00a0months, Group\n                      <jats:styled-content style=\"fixed-case\">CTG<\/jats:styled-content>\n                      attained a mean width of keratinized tissue of 2.75 (1.5)\u00a0mm, while the corresponding figure in Group\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      was 2.8 (0.4)\u00a0mm, the inter\u2010group differences not being statistically significant. The surgical procedure in both groups did not alter significantly the mucosal health in the affected abutments. There was a similar esthetic result and significant increase in the vestibular depth in both groups as a result of the surgery. In the\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      group it changed from 2.2 (3.3) to 5.1 (2.5)\u00a0mm at 6\u00a0months. The patients treated with the\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      referred less pain, needed less pain medication, and the surgical time was shorter, although these differences were not statistically significant when compared with the\n                      <jats:styled-content style=\"fixed-case\">CTG<\/jats:styled-content>\n                      group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results prove that this new CM was as effective and predictable as the CTG for attaining a band of keratinized tissue.<\/jats:p>\n                  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