{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T01:30:25Z","timestamp":1775871025913,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,9,5]],"date-time":"2011-09-05T00:00:00Z","timestamp":1315180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this investigation was to evaluate the potential effects of the systemically delivered combination of calcium supplementation and cholecalciferol and of the locally applied biphasic calcium alloplast on the surgically produced alveolar sockets at the early healing stage in a dog model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The mandibular pre\u2010molars of nine Beagle dogs were extracted first. Three months later, four standardized sockets with a 4\u00a0mm in diameter and 6\u00a0mm deep cylinder were created bilaterally at healed extraction sites. The sockets on one side were grafted with biphasic calcium phosphate alloplast, whereas the defects on the other side were left un\u2010grafted. The dogs were then randomly divided into two groups; five dogs received oral calcium and cholecalciferol combination (Vit.D\/Ca) and were assigned to the test group (<jats:italic>Vit.D\/Ca Group<\/jats:italic>). The other four dogs without Vit.D\/Ca supplement were distributed to the control group (<jats:italic>Non\u2010Vit.D\/Ca Group<\/jats:italic>). The bone density (<jats:italic>Density<\/jats:italic>) and the implant stability quotient (<jats:styled-content style=\"fixed-case\">ISQ<\/jats:styled-content>) at prepared sites were measured 4\u00a0weeks later. The drawn bone cores were examined by a histomorphometric analysis for measurement of new bone formation (<jats:styled-content style=\"fixed-case\">NBF<\/jats:styled-content>). The amount of vertical ridge resorption (<jats:styled-content style=\"fixed-case\">VRR<\/jats:styled-content>) was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Vit.D\/Ca\u2010treated subjects revealed significantly more<jats:styled-content style=\"fixed-case\">NBF<\/jats:styled-content>(<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), higher bone density (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and significantly less vertical ridge reduction (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) in the healing sockets than those without Vit.D\/Ca treatment. The non\u2010grafted sockets demonstrated significantly more<jats:styled-content style=\"fixed-case\">NBF<\/jats:styled-content>(<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), higher bone density (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), better<jats:styled-content style=\"fixed-case\">ISQ<\/jats:styled-content>value (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and more vertical ridge reduction (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) than those in the grafted sockets. There was no significant difference between the serum data determined before and 4\u00a0weeks after experiment in Vit.D\/Ca Group or Non\u2010Vit.D\/Ca Group. However, the changed value (post\u2010op vs. pre\u2010op) between the two groups was significant in the serum level of phosphate and parathyroid hormone (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of the present study indicated that the examined calcium phosphate alloplast may perform a function in alveolar ridge preservation while reducing the potential of<jats:styled-content style=\"fixed-case\">NBF<\/jats:styled-content>potential in the healing extraction socket. Also, the combination of calcium supplementation and cholecalciferol may have systemic effects on accelerating bone regeneration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0501.2011.02284.x","type":"journal-article","created":{"date-parts":[[2011,9,5]],"date-time":"2011-09-05T09:39:28Z","timestamp":1315215568000},"page":"1187-1192","source":"Crossref","is-referenced-by-count":17,"title":["The potential effects of cholecalciferol on bone regeneration in dogs"],"prefix":"10.1111","volume":"23","author":[{"given":"Hsiang\u2010Hsi","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Periodontics Chang Gung Memorial Hospital at Linkou Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting\u2010An","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Periodontics Chang Gung Memorial Hospital at Linkou Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen\u2010Chang","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Dentistry College of Oral Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chee\u2010Jen","family":"Chang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science Clinical Informatics and Medical Statistics Research Center Chang Gung University Taoyuan Taiwan"},{"name":"Biostatistical Center for Clinical Research Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01606.x"},{"key":"e_1_2_6_3_1","first-page":"123","article-title":"The influence of Bio\u2010Oss Collagen on healing of an extraction socket: an experimental study in the dog","volume":"28","author":"Ara\u00fajo M.G.","year":"2008","journal-title":"The International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00642.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01705.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.6.1015"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.12.1128"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.10.1025"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.12.029"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-006-0542-7"},{"key":"e_1_2_6_11_1","first-page":"171","article-title":"1\u03b1, 25\u2010Dihydroxyvitamin D3: a metabolite of vitamin D3 that promotes bone repair","volume":"106","author":"Brumbaugh P.F.","year":"1982","journal-title":"American Journal of Pathology"},{"key":"e_1_2_6_12_1","volume-title":"Nonparametric Analysis of Longitudinal Data in Factorial Experiments","author":"Brunner E.","year":"2002"},{"key":"e_1_2_6_13_1","volume-title":"Nichtparametrische Analyse Longitudinaler Daten","author":"Brunner E.","year":"1999"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212033272305"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980200023"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(97)00054-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709043371003"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0650429"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100160604"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/ajcn\/80.1.108","article-title":"Association between serum concentrations of 25\u2010hydroxyvitamin D3 and periodontal disease in the US population","volume":"80","author":"Dietrich T.","year":"2004","journal-title":"American Journal of Clinical Nutrition"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00336.2004"},{"key":"e_1_2_6_22_1","first-page":"29","article-title":"Clinical and histologic evaluation of bone replacement grafts in the treatment of localized alveolar ridge defects. 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