{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T01:15:55Z","timestamp":1752282955755},"reference-count":26,"publisher":"Wiley","issue":"A100","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study utilized the constitution and expression of Runx2\/Cbfa1 to conduct 6\u2010month\u2010post\u2010operation histomorphometrical and histochemical analysis of osteocalcin in bone regeneration following sinus\u2010floor augmentation procedures using \u03b2\u2010tricalcium phosphate (\u03b2\u2010<jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content>) and autogenous cortical bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Thirteen sinuses of nine patients were treated with sinus\u2010floor augmentation using 50% \u03b2\u2010<jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content> and 50% autogenous cancellous bone harvested from the ramus of the mandible. Biopsies of augmented sinuses were taken at 6\u00a0months for histomorphometric and immunohistochemical measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Runx2\/Cbfa1\u2010 and osteocalcin\u2010positive cells were found around <jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content> particles and on the bone surface. Approximately 60% of cells found around <jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content> particles stained positive for Runx2\/Cbfa1. Fewer cells stained positive for osteocalcin. These positive cells decreased apically with increasing vertical distance from the maxillary bone surface. Histomorphometric analysis showed that the augmented site close to residual bone and periosteum contained approximately 42% bony tissue and 42% soft connective tissue, and the remaining 16% consisted of <jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content> particles. On the other hand, the augmented bone far from residual bone and periosteum contained 35% bony tissue and 50% soft connective tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest that <jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content> particles attract osteoprogenitor cells that migrate into the interconnecting micropores of the bone\u2010substitute material by 6\u00a0months. The augmented site close to residual bone contained a higher proportion of bony tissue and a lower proportion of soft connective tissue than did the augmented site far from residual bone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0501.2011.02396.x","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T11:28:07Z","timestamp":1325849287000},"page":"134-138","source":"Crossref","is-referenced-by-count":10,"title":["Histomorphometric and immunohistochemical analysis of human maxillary sinus\u2010floor augmentation using porous \u03b2\u2010tricalcium phosphate for dental implant treatment"],"prefix":"10.1111","volume":"24","author":[{"given":"Shinji","family":"Miyamoto","sequence":"first","affiliation":[{"name":"Division of Oral and Maxillofacial Reconstructive Surgery Department of Oral and Maxillofacial Surgery Science of Physical Functions Kyushu Dental College Kitakyusyu City 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