{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:44:53Z","timestamp":1767163493390,"version":"build-2238731810"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T00:00:00Z","timestamp":1327536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to carry out an ultrastructural study of the biomaterial\u2010to\u2010bone interface and biomaterial mineral degradation in retrieved bone biopsies following maxillary sinus augmentation using collagenized porcine xenografts (Osteobiol\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Mp3) in 15 clinical cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Nine months after sinus lifting, bone cores were harvested from the maxillary sinus. The specimens were processed for observation under a scanning electron microscope with backscattered electron imaging (\n                      <jats:styled-content style=\"fixed-case\">SEM<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">BSE<\/jats:styled-content>\n                      ). In addition, chemical analysis and elemental mapping of the mineral composition were generated using a microanalytical system based on energy\u2010dispersive\n                      <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\n                      \u2010ray spectrometry (\n                      <jats:styled-content style=\"fixed-case\">EDX<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No clinical complications were evident during surgery. Scanning electron microscopy revealed that newly formed bone had become closely attached to the xenograft. Statistical analysis showed a significantly high\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:roman>Ca<\/jats:roman>\n                      <\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:roman>P<\/jats:roman>\n                      <\/jats:styled-content>\n                      ratio in the biomaterial (2.46\u00a0\u00b1\u00a00.16) and at the bone interface (2.00\u00a0\u00b1\u00a00.48) compared to bone (1.97\u00a0\u00b1\u00a00.36), which suggests that there may be a gradual diffusion of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:roman>Ca<\/jats:roman>\n                      <\/jats:styled-content>\n                      ions from the biomaterial into the newly forming bone at the interface as part of the biomaterial's resorption process.\n                      <jats:styled-content style=\"fixed-case\">EDX<\/jats:styled-content>\n                      analysis of the residual porcine biomaterial at different points showed some particle categories with different mean ratios of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:roman>Ca<\/jats:roman>\n                      <\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:roman>P<\/jats:roman>\n                      <\/jats:styled-content>\n                      according to size, pointing to different stages of the resorption process.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The biomaterial proved to be biocompatible, bioreabsorbable and osteoconductive when used as a bone substitute for maxillary sinus elevation.\n                      <jats:styled-content style=\"fixed-case\">SEM<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">BSE<\/jats:styled-content>\n                      revealed that newly formed bone had become closely attached to the xenografts.\n                      <jats:styled-content style=\"fixed-case\">EDX<\/jats:styled-content>\n                      analysis monitored the resorption process of the porcine bone xenograft. Elemental mapping showed that there was a gradual diffusion of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:roman>Ca<\/jats:roman>\n                      <\/jats:styled-content>\n                      ions from the biomaterial to the newly forming bone at the interface.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1600-0501.2011.02414.x","type":"journal-article","created":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T04:47:43Z","timestamp":1327553263000},"page":"523-530","source":"Crossref","is-referenced-by-count":19,"title":["RETRACTED: Ultrastructural study by backscattered electron imaging and elemental microanalysis of bone\u2010to\u2010biomaterial interface and mineral degradation of porcine xenografts used in maxillary sinus floor elevation"],"prefix":"10.1111","volume":"24","author":[{"given":"Maria Piedad","family":"Ram\u00edrez\u2010Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Implant Dentistry Faculty of Medicine and Dentistry University of Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Luis","family":"Calvo\u2010Guirado","sequence":"additional","affiliation":[{"name":"Department of Implant Dentistry Faculty of Medicine and Dentistry University of Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Eduardo","family":"Mat\u00e9\u2010S\u00e1nchez del Val","sequence":"additional","affiliation":[{"name":"Department of Implant Dentistry Faculty of Medicine and Dentistry University of Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Arcesio","family":"Delgado\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Department of Implant Dentistry Faculty of Medicine and Dentistry University of Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Negri","sequence":"additional","affiliation":[{"name":"Department of Implant Dentistry Faculty of Medicine and Dentistry University of Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Barona\u2010Dorado","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Complutense University of Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,26]]},"reference":[{"issue":"1","key":"e_1_2_6_2_1","first-page":"49","article-title":"Which hard tissue augmentation techniques are the most successful in furnishing bony support for the implant placement?","volume":"22","author":"Aghaloo T.L.","year":"2007","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_3_1","first-page":"351","article-title":"Clinical and histological study of a xenogenic bone substitute used as a filler in postextractive alveolus","volume":"54","author":"Arcuri C.","year":"2005","journal-title":"Minerva Stomatologica"},{"key":"e_1_2_6_4_1","first-page":"519","article-title":"Maxillary sinus augmentation: histologic and histomorphometric analysis","volume":"20","author":"Barone A.","year":"2005","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708\u20108208.2010.00274.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/088532829000500105"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1086\/647830","article-title":"Microbiological hazards related to xenotransplantation of porcine organs into man","volume":"19","author":"Borie D.C.","year":"1998","journal-title":"Infection Control and Hospital Epidemiology"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2011.02193.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708\u20108208.2011.00337.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2003.tb00198.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1615\/JLongTermEffMedImplants.v16.i3.50"},{"key":"e_1_2_6_12_1","first-page":"696","article-title":"The efficacy of various bone augmentation procedures for dental implants: a Cochrane systematic review of randomized controlled clinical trials","volume":"21","author":"Esposito M.","year":"2006","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1632619"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20748"},{"key":"e_1_2_6_15_1","first-page":"1051","article-title":"Bone ingrowth into porous coated canine total hip replacements. 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