{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:49:53Z","timestamp":1767980993329,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T00:00:00Z","timestamp":1327536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Implant dentistry in the posterior maxilla often requires bone augmentation. The gold standard, autogenous bone graft, requires additional surgery with associated morbidity, while bone biomaterials may not support relevant bone formation. Recombinant human bone morphogenetic protein\u20102 (<jats:styled-content style=\"fixed-case\">rhBMP<\/jats:styled-content>\u20102) in an absorbable collagen sponge (<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>), however, induces significant, clinically relevant bone formation in several settings including the maxillary sinus floor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to compare local bone formation and osseointegration following maxillary sinus augmentation using <jats:styled-content style=\"fixed-case\">rhBMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> or a particulate autogenous cancellous bone graft obtained from the iliac crest in conjunction with immediate placement of dental implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Bilateral sinus augmentation using an extraoral approach including <jats:styled-content style=\"fixed-case\">rhBMP<\/jats:styled-content>\u20102 (0.43\u00a0mg\/ml)\/ACS or the autogenous bone graft, alternated between left and right sinus cavities in five adult male <jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content>ucatan mini\u2010pigs, was performed. Two 12\u2010mm dental implants were inserted into the sinus wall protruding approximately 8\u00a0mm into the sinus cavity. Surgical sites were closed and sutured in layers; block biopsies collected for histometric analysis at 8\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">rhBMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> induced bone of significantly greater and consistent quality compared with the iliac crest autogenous bone graft; bone density averaging 51.9\u00a0\u00b1\u00a03.0% vs. 32.9\u00a0\u00b1\u00a02.5% (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.01). However, there were only numerical differences in augmented bone height (9.3\u00a0\u00b1\u00a00.5 vs. 8.6\u00a0\u00b1\u00a00.7\u00a0mm) and bone\u2010implant contact (37.4\u00a0\u00b1\u00a03.0% vs. 30.7\u00a0\u00b1\u00a05.9%) between treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">rhBMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> induces bone of superior quality compared with an iliac crest particulate autogenous cancellous bone graft when used for maxillary sinus augmentation, and should perhaps be considered the new standard for this indication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0501.2011.02419.x","type":"journal-article","created":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T09:46:34Z","timestamp":1327571194000},"page":"497-504","source":"Crossref","is-referenced-by-count":34,"title":["Sinus augmentation using <scp>rhBMP\u20102\/ACS<\/scp> in a mini\u2010pig model: relative efficacy of autogenous fresh particulate iliac bone grafts"],"prefix":"10.1111","volume":"24","author":[{"given":"Jaebum","family":"Lee","sequence":"first","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration Departments of Periodontics and Oral Biology Georgia Health Sciences University College of Dental Medicine Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano","family":"Susin","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration Departments of Periodontics and Oral Biology Georgia Health Sciences University College of Dental Medicine Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy A.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Laboratory Animal Services Georgia Health Sciences University Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"de Stefano","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration Departments of Periodontics and Oral Biology Georgia Health Sciences University College of Dental Medicine Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hari S.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Hard Tissue Research Laboratory Division of Oral and Maxillofacial Pathology University of Minnesota School of Dentistry Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda N.","family":"Buxton","sequence":"additional","affiliation":[{"name":"Biologics Product Development Medtronic Inc. 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