{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:29:14Z","timestamp":1767983354481,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T00:00:00Z","timestamp":1329264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this pre\u2010clinical study was to evaluate the biological performance of two injectable calcium phosphate cement (<jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>) composite materials containing poly(D,L\u2010lactic\u2010<jats:italic>co<\/jats:italic>\u2010glycolic)acid (<jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content>) microspheres with different properties in a maxillary sinus floor elevation model in sheep.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content> microspheres were made of either low molecular weight (~17\u00a0kDa) acid\u2010terminated <jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content><jats:sub>L\u2010AT<\/jats:sub>) or high molecular weight (~44\u00a0kDa) end\u2010capped <jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content><jats:sub>H\u2010EC<\/jats:sub>) and incorporated in <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>. Eight female Swifter sheep underwent a bilateral maxillary sinus floor elevation procedure via an extra\u2010oral approach. All animals received both materials, alternately injected in the left and right sinus (split\u2010mouth model) and a time point of 12\u00a0weeks was used. Analysis of biological performance was based on histology, histomorphometry, and evaluation of sequential fluorochrome labeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both types of <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content> composites showed biocompatibility and direct bone\u2010cement contact. <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content><jats:sub>L\u2010AT<\/jats:sub> showed a significantly higher degradation distance compared to <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content><jats:sub>H\u2010EC<\/jats:sub> (1949\u00a0\u00b1\u00a01295\u00a0\u03bcm vs. 459\u00a0\u00b1\u00a0267\u00a0\u03bcm; <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.0107). Further, <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content><jats:sub>L\u2010AT<\/jats:sub> showed significantly more bone in the region of interest (26.4\u00a0\u00b1\u00a010.5% vs. 8.6\u00a0\u00b1\u00a03.9% for <jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content><jats:sub>H\u2010EC<\/jats:sub>; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0009) and significantly less remaining <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content> material (61.2\u00a0\u00b1\u00a017.7% vs. 81.9\u00a0\u00b1\u00a010.9% for <jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content><jats:sub>H\u2010EC<\/jats:sub>; <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.0192).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content><jats:sub>L\u2010AT<\/jats:sub> and <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content><jats:sub>H\u2010EC<\/jats:sub> demonstrated to be safe materials for sinus floor elevation procedures in a large animal model, presenting biocompatibility and direct bone contact. In view of material performance, <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content><jats:sub>L\u2010AT<\/jats:sub> showed significantly faster degradation and a significantly higher amount of newly formed bone compared to <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content><jats:sub>H\u2010EC<\/jats:sub>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0501.2012.02421.x","type":"journal-article","created":{"date-parts":[[2012,2,16]],"date-time":"2012-02-16T02:42:55Z","timestamp":1329360175000},"page":"210-216","source":"Crossref","is-referenced-by-count":20,"title":["Maxillary sinus floor augmentation with injectable calcium phosphate cements: a pre\u2010clinical study in sheep"],"prefix":"10.1111","volume":"24","author":[{"given":"Jan Willem M.","family":"Hoekstra","sequence":"first","affiliation":[{"name":"Department of Biomaterials Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinoud J.","family":"Klijn","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert J.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Implantology and Periodontology Radboud University Nijmegen Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen J. 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