{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:09:17Z","timestamp":1789013357711,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T00:00:00Z","timestamp":1335225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n \n The objective was to test the hypotheses: (i) no differences in bone\u2010to\u2010implant contact formation, and (ii) no differences between the use of autogenous mandibular or iliac bone grafts, when autogenous bone,\n B<\/jats:styled-content>\n io\u2010\n O<\/jats:styled-content>\n ss mixed with autogenous bone, or\n B<\/jats:styled-content>\n io\u2010\n O<\/jats:styled-content>\n ss is used as graft for the maxillary sinus floor augmentation.\n <\/jats:p>\n <\/jats:sec>\n \n Material and methods<\/jats:title>\n \n Bilateral sinus floor augmentation was performed in 40 mini pigs with: (A) 100% autogenous bone, (B) 75% autogenous bone and 25%\n B<\/jats:styled-content>\n io\u2010\n O<\/jats:styled-content>\n ss, (C) 50% autogenous bone and 50%\n B<\/jats:styled-content>\n io\u2010\n O<\/jats:styled-content>\n ss, (D) 25% autogenous bone and 75%\n B<\/jats:styled-content>\n io\u2010\n O<\/jats:styled-content>\n ss, or (E) 100%\n B<\/jats:styled-content>\n io\u2010\n O<\/jats:styled-content>\n ss. Autogenous bone was harvested from the iliac crest or the mandible and the graft composition was selected at random and placed concomitant with the implant placement. The animals were euthanized 12\u00a0weeks after surgery. Bone\u2010to\u2010implant contact was estimated by stereological methods and summarized as median percentage with 95% confidence interval (\n CI<\/jats:styled-content>\n ). Bone\u2010to\u2010implant contact formation was evaluated by fluorochrome labelling and assessed by median odds ratios (\n OR<\/jats:styled-content>\n ) with 95% (\n CI<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Median bone\u2010to\u2010implant contact was: (A) 42.9% (95%\n CI<\/jats:styled-content>\n : 32.1\u201354.5%), (B) 37.8% (95%\n CI<\/jats:styled-content>\n : 27.1\u201349.9%), (C) 43.9% (95%\n CI<\/jats:styled-content>\n : 32.6\u201355.9%), (D) 30.2% (95%\n CI<\/jats:styled-content>\n : 21.6\u201340.3%), and (E) 13.9% (95%\n CI<\/jats:styled-content>\n : 11.4\u201316.9%). Bone\u2010to\u2010implant contact was significantly higher for A, B, C, D as compared to E (\n P\u00a0<\/jats:italic>\n <\u00a00.0001). Bone\u2010to\u2010implant contact was not significantly influenced by the ratio of\n B<\/jats:styled-content>\n io\u2010\n O<\/jats:styled-content>\n ss and autogenous bone (\n P\u00a0<\/jats:italic>\n =\u00a00.19) or the origin of the autogenous bone (\n P\u00a0<\/jats:italic>\n =\u00a00.72). Fluorochrome labelling revealed extensive variation in bone\u2010to\u2010implant contact formation over time. The labelling at weeks 2\u20133 was significantly increased with A compared to E (\n OR<\/jats:styled-content>\n \u00a0=\u00a08.1\n CI<\/jats:styled-content>\n : 5.0\u201313.1,\n P\u00a0<\/jats:italic>\n <\u00a00.0001), whereas E showed a significantly increased labelling at weeks 8\u20139 compared to A (\n OR<\/jats:styled-content>\n \u00a0=\u00a00.5\n CI<\/jats:styled-content>\n : 0.3\u20130.7,\n P\u00a0<\/jats:italic>\n =\u00a00.0028).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The hypothesis of no differences in bone\u2010to\u2010implant contact between the various treatment modalities was rejected since the bone\u2010to\u2010implant contact was significantly increased with autogenous bone or\n B<\/jats:styled-content>\n io\u2010\n O<\/jats:styled-content>\n ss mixed with autogenous bone as compared to\n B<\/jats:styled-content>\n io\u2010\n O<\/jats:styled-content>\n ss. Early bone\u2010to\u2010implant contact formation was more advanced with autogenous bone. No differences between the use of mandibular or iliac bone grafts were observed since the bone\u2010to\u2010implant contact was not significantly influenced by the origin of the bone graft.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1600-0501.2012.02438.x","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T23:38:17Z","timestamp":1335310697000},"page":"635-644","source":"Crossref","is-referenced-by-count":46,"title":["Bone\u2010to\u2010implant contact after maxillary sinus floor augmentation with\n B<\/scp>\n io\u2010\n O<\/scp>\n ss and autogenous bone in different ratios in mini pigs"],"prefix":"10.1111","volume":"24","author":[{"given":"Thomas","family":"Jensen","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Aalborg Hospital Aarhus University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Schou","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Oral Pathology School of Dentistry Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J\u00f8rgen G.","family":"Gundersen","sequence":"additional","affiliation":[{"name":"Stereology and Electron Microscopy Research Laboratory Aarhus Hospital Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie Lyng","family":"Forman","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Terheyden","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Red Cross Hospital Kassel Kassel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palle","family":"Holmstrup","sequence":"additional","affiliation":[{"name":"Departments of Periodontology Schools of Dentistry Universities of Copenhagen and Aarhus Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1986.tb04282.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2007.00050.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2004.07.017"},{"key":"e_1_2_6_6_1","first-page":"117","article-title":"Stevenel\u2032s blue, an excellent stain for optical microscopical study of plastic embedded tissues","volume":"83","author":"del Cerro M.","year":"1980","journal-title":"Microscopic Acta"},{"key":"e_1_2_6_7_1","first-page":"237","article-title":"Bone augmentation procedures in implant dentistry","volume":"24","author":"Chiapasco M.","year":"2009","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_8_1","first-page":"CD008397","article-title":"Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus","volume":"17","author":"Espositio M.","year":"2010","journal-title":"Cochrane Database Systematic Reviews"},{"key":"e_1_2_6_9_1","first-page":"565","article-title":"Systematic review of survival rates for implants placed in the grafted maxillary sinus","volume":"24","author":"del Fabbro M.","year":"2004","journal-title":"The International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.00859.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02073.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02892580"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2818.1999.00457.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2009.06.226"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1998.090206.x"},{"key":"e_1_2_6_16_1","first-page":"635","article-title":"A clinical and histologic evaluation of implant integration in the posterior maxilla after sinus floor augmentation with autogenous bone, bovine hydroxyapatite, or a 20:80 mixture","volume":"17","author":"Hallman M.","year":"2002","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-160X-5-12"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1997.080606.x"},{"key":"e_1_2_6_19_1","article-title":"Volumetric changes of the graft after maxillary sinus floor augmentation with Bio\u2010Oss and autogenous bone in different ratios. 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