{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:24:22Z","timestamp":1792808662605,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T00:00:00Z","timestamp":1335744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze hard tissue reactions to immediate functionally loaded single implants that were installed either with a conventional drill preparation procedure or with an osteotome preparation technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Thirteen subjects with two sites requiring single tooth rehabilitation by means of implants volunteered for the study. Each subject received one test (immediate functionally loaded) and one control (non\u2010loaded) implant. In six subjects (group 1) the implants were placed using a conventional drilling procedure, whereas in the remaining seven subjects (group 2) an osteotome preparation procedure was performed. Block biopsies containing test and control implants and peri\u2010implant bone tissues were collected at 1\u00a0month in four of the subjects in group 1 and in five subjects of group 2. The remaining implant sites were sampled at 3\u00a0months after implant placement. The biopsies were prepared for histological examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two implants of the test\u20102 group (osteotome preparation) representing 1\u00a0month of healing and another test\u20102 implant representing 3\u00a0months of healing failed to integrate. A multilevel multivariate statistical analysis demonstrated that no differences in bone\u2010to\u2010implant contact (<jats:styled-content style=\"fixed-case\">BIC<\/jats:styled-content>)% were found in between test and control implants, the density of newly formed peri\u2010implant bone was significantly higher around test than control implants at 1 and 3\u00a0months of healing. Sections representing osteotome technique sites showed fractured trabeculae and large amounts of bone particles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is suggested that immediate loading of implants does not influence the osseointegration process, whereas the density of newly formed peri\u2010implant bone at such sites appears to be increased in relation to unloaded control implants. The use of an osteotome preparation technique during installation results in damage of peri\u2010implant bone and enhances the risk for failure in osseointegration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0501.2012.02479.x","type":"journal-article","created":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T06:52:27Z","timestamp":1335768747000},"page":"738-745","source":"Crossref","is-referenced-by-count":38,"title":["Effect of immediate functional loading on osseointegration of implants used for single tooth replacement. A human histological study"],"prefix":"10.1111","volume":"24","author":[{"given":"Mauro","family":"Donati","sequence":"first","affiliation":[{"name":"Department of Periodontology The Sahlgrenska Academy at University of Gothenburg, Private practice Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Botticelli","sequence":"additional","affiliation":[{"name":"Ariminum Odontologica, Oral Surgery Division Rimini Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"La Scala","sequence":"additional","affiliation":[{"name":"Private practice Pistoia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Tomasi","sequence":"additional","affiliation":[{"name":"Department of Periodontology The Sahlgrenska Academy at University of Gothenburg, Private practice Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tord","family":"Berglundh","sequence":"additional","affiliation":[{"name":"Department of Periodontology The Sahlgrenska Academy at University of Gothenburg"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01082.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01309.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.00972.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00747.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2007.00039.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01111.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2003.tb00018.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02293.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1563\/1548-1336(2003)029<0223:HEOHIL>2.3.CO;2"},{"key":"e_1_2_6_11_1","first-page":"896","article-title":"Bone formation around immediately loaded and submerged dental implants with a modified sandblasted and acid\u2010etched surface after 4 and 8\u00a0weeks: a human histologic and histomorphometric analysis","volume":"24","author":"Degidi M.","year":"2009","journal-title":"International Journal of Oral Maxillofacial Implants"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2003.tb00189.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1982.tb00172.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01552.x"},{"key":"e_1_2_6_15_1","first-page":"CD003878","article-title":"Interventions for replacing missing teeth: different times for loading dental implants","author":"Esposito M.","year":"2009","journal-title":"Cochrane Database Systematic Review"},{"issue":"1","key":"e_1_2_6_16_1","first-page":"S52","article-title":"Immediate occlusal loading of Br\u00e5nemark System TiUnite implants placed predominantly in soft bone: 4\u2010year results of a prospective clinical study","volume":"7","author":"Glauser R.","year":"2005","journal-title":"Clinical Implant Dentistry and Related Research"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100751"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02172.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2008.08.023"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.02.015"},{"key":"e_1_2_6_21_1","first-page":"540","article-title":"Immediate versus delayed loading of dental implants in the maxillae of minipigs. Part II: histomorphometric analysis","volume":"20","author":"Nkenke E.","year":"2005","journal-title":"International Journal of Oral Maxillofacial Implants"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130604.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2003.tb00020.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e3181991248"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-09-00060"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11.1823"},{"key":"e_1_2_6_27_1","first-page":"44","article-title":"Histologic and histomorphometric evaluation of peri\u2010implant bone subjected to immediate loading: an experimental study with Macaca fascicularis","volume":"17","author":"Romanos G.E.","year":"2002","journal-title":"International Journal of Oral Maxillofacial Implants"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1973.tb04629.x"},{"key":"e_1_2_6_29_1","first-page":"152","article-title":"A new concept in maxillary implant surgery: the osteotome technique","volume":"15","author":"Summers R.B.","year":"1994","journal-title":"Compendium"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0501.2012.02479.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0501.2012.02479.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T08:53:48Z","timestamp":1697619228000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0501.2012.02479.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,30]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/j.1600-0501.2012.02479.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0501.2012.02479.x","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,30]]}}}