{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:21:45Z","timestamp":1793305305439,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T00:00:00Z","timestamp":1336521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the adjunctive clinical effects in the non\u2010surgical treatment of peri\u2010implantitis with either local drug delivery (<jats:styled-content style=\"fixed-case\">LDD<\/jats:styled-content>) or photodynamic therapy (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Forty subjects with initial peri\u2010implantitis, i.e. pocket probing depths (<jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>) 4\u20136\u00a0mm with concomitant bleeding on probing (<jats:styled-content style=\"fixed-case\">BoP<\/jats:styled-content>) and marginal bone loss ranging from 0.5 to 2\u00a0mm between delivery of the reconstruction and pre\u2010screening appointment were randomly assigned to two treatment groups. All implants underwent mechanical debridement with titanium curettes, followed by a glycine\u2010based powder airpolishing. Implants in the test group (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) received adjunctive <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>, whereas minocycline microspheres were locally delivered into the peri\u2010implant pockets of control implants (<jats:italic>n<\/jats:italic>\u00a0=\u00a020). At sites with residual <jats:styled-content style=\"fixed-case\">BoP<\/jats:styled-content>, treatment was repeated after 3 and 6\u00a0months. The primary outcome variable was the change in the number of sites with <jats:styled-content style=\"fixed-case\">BoP<\/jats:styled-content>. Secondary outcome variables were changes in <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>, in clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>), and in mucosal recession (<jats:styled-content style=\"fixed-case\">REC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 3\u00a0months, implants of both groups yielded a statistically significant reduction (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) in the number of <jats:styled-content style=\"fixed-case\">BoP<\/jats:styled-content>\u2010positive sites compared with baseline (<jats:styled-content style=\"fixed-case\">LDD<\/jats:styled-content>: from 4.41\u00a0\u00b1\u00a01.47 to 2.20\u00a0\u00b1\u00a01.28, <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>: from 4.03\u00a0\u00b1\u00a01.66 to 2.26\u00a0\u00b1\u00a01.28). After 6\u00a0months, complete resolution of mucosal inflammation was obtained in 15% of the implants in the control group and in 30% of the implants in the test group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.16). After 3\u00a0months, changes in <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> REC<\/jats:styled-content>, and modified Plaque Index (mPlI) were statistically significantly different from baseline (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). No statistically significant changes (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05) occurred between 3 and 6\u00a0months. <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> measurements did not yield statistically significant changes (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05) in both groups during the 6\u2010month observation time. Between\u2010group comparisons revealed no statistically significant differences (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05) at baseline, 3 and 6\u00a0months with the exception of the mPlI after 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In cases of initial peri\u2010implantitis, non\u2010surgical mechanical debridement with adjunctive use of <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> is equally effective in the reduction of mucosal inflammation as with the adjunctive use of minocycline microspheres up to 6\u00a0months. Adjunctive <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> may represent an alternative treatment modality in the non\u2010surgical management of initial peri\u2010implantitis. Complete resolution of inflammation, however, was not routinely achieved with either of the adjunctive therapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0501.2012.02494.x","type":"journal-article","created":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T09:29:27Z","timestamp":1336555767000},"page":"104-110","source":"Crossref","is-referenced-by-count":150,"title":["Anti\u2010infective therapy of peri\u2010implantitis with adjunctive local drug delivery or photodynamic therapy: six\u2010month outcomes of a prospective randomized clinical trial"],"prefix":"10.1111","volume":"24","author":[{"given":"Dorothee","family":"Sch\u00e4r","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph A.","family":"Ramseier","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun","family":"Eick","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole B.","family":"Arweiler","sequence":"additional","affiliation":[{"name":"Department of Periodontology Philipps University  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni E.","family":"Salvi","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern  Bern 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