{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:33:04Z","timestamp":1787761984975,"version":"build-2784847793"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T00:00:00Z","timestamp":1339977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the levels of biomarkers associated with osteoclastogenesis in patients suffering peri\u2010implantitis and to compare them with levels in healthy peri\u2010implant sites and severe chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Peri\u2010implant\/gingival crevicular fluid samples and clinical parameters including: bleeding on probing, modified Plaque Index (PlI), pocket depth and clinical attachment level were collected from 70 patients (23 with peri\u2010implantitis, 25 with healthy peri\u2010implant tissues and 22 with severe chronic periodontitis). The concentrations of <jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content>, RANK and OPG were evaluated using enzyme\u2010linked immunosorbent assays; they were compared between the groups and correlated with the clinical findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01), RANK (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and OPG (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) concentrations were significantly higher in peri\u2010implantitis sites when compared to those in healthy implant sites, although differences in the <jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content>\/OPG ratio were not statistically significant. In these sites all three markers were significantly correlated with the clinical parameters, with exception of OPG\/PI correlation that remained insignificant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.121). When comparing peri\u2010implantitis and periodontitis findings, RANK was significantly higher in peri\u2010implantitis sites whereas, <jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and <jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content>\/OPG ratio (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) were significantly higher in periodontitis sites. Among periodontitis and healthy implant sites the same differences have been observed for both <jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.000) and <jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content>\/OPG ratio (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.000), furthermore RANK was higher in periodontitis sites as well (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings of this preliminary study on a relatively small sample size suggest that the PICF levels of biomarkers <jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content>, RANK, and OPG are associated with peri\u2010implant tissue destruction and the pattern of these biomarkers differed when compared to periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0501.2012.02518.x","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T16:57:59Z","timestamp":1340038679000},"page":"1110-1116","source":"Crossref","is-referenced-by-count":64,"title":["Bone loss biomarkers associated with peri\u2010implantitis. A cross\u2010sectional study"],"prefix":"10.1111","volume":"24","author":[{"given":"Mia","family":"Rakic","sequence":"first","affiliation":[{"name":"Department for Periodontology and Oral Medicine Faculty of Dental Medicine University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vojislav","family":"Lekovic","sequence":"additional","affiliation":[{"name":"Department for Periodontology and Oral Medicine Faculty of Dental Medicine University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasa","family":"Nikolic\u2010Jakoba","sequence":"additional","affiliation":[{"name":"Department for Periodontology and Oral Medicine Faculty of Dental Medicine University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Vojvodic","sequence":"additional","affiliation":[{"name":"Institute for Medical Research Military Medical Academy Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Petkovic\u2010Curcin","sequence":"additional","affiliation":[{"name":"Institute for Medical Research Military Medical Academy Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Sanz","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal Disease (ETEP) Research Group University Complutense of Madrid Madrid 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