{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:45:54Z","timestamp":1790815554958,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,7,12]],"date-time":"2012-07-12T00:00:00Z","timestamp":1342051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>As a consequence of extraction, the height of the buccal wall tends to decrease and results in the disappearance of bundle bone. To modify bone remodelling after extraction, various ridge preservation techniques have been proposed. The present research was drawn up with the following considerations in mind: to evaluate and to compare changes of hard and soft tissues in post\u2010extraction sockets which received a ridge preservation procedure, with post\u2010extraction sockets which had healed naturally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Each patient was randomly allocated to a test or control group using a specific software package. After extraction, the sockets were carefully inspected and any granulation tissue was removed. The control sites received silk sutures to stabilize the clot without any grafting material. The test sites were grafted with corticocancellous porcine bone and a collagen membrane. All experimental sites had the membranes left exposed to the oral cavity with a secondary wound healing. The thickness of the buccal alveolar bone, if present, was carefully measured at the time of tooth extraction using a calliper at 1\u00a0mm from the edge of the wall. The following clinical parameters were evaluated at baseline and after 4\u00a0months at implant placement: vertical bone changes, horizontal bone changes and width of keratinized gingiva. The length, diameter and need for additional bone augmentation were assessed for both groups at the time of implant insertion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The control group showed vertical bone resorption of 1\u00a0\u00b1\u00a00.7\u00a0mm, 2.1\u00a0\u00b1\u00a00.6\u00a0mm, 1\u00a0\u00b1\u00a00.8\u00a0mm and 2\u00a0\u00b1\u00a00.73\u00a0mm at the mesial, vestibular, distal and lingual sites respectively. Moreover, changes in horizontal dimension showed an average resorption of 3.6\u00a0\u00b1\u00a00.72\u00a0mm. The test sites showed a horizontal bone remodelling of 0.3\u00a0\u00b1\u00a00.76\u00a0mm, 1.1\u00a0\u00b1\u00a00.96\u00a0mm, 0.3\u00a0\u00b1\u00a00.85\u00a0mm, 0.9\u00a0\u00b1\u00a00.98\u00a0mm at the mesial, vestibular, distal and lingual sites respectively. The horizontal bone resorption at the test sites was 1.6\u00a0\u00b1\u00a00.55\u00a0mm. The keratinized gingiva showed a coronal shift of 0.7\u00a0mm in the control group when compared to 1.1\u00a0mm in the test group. In addition, 42% of sites in the control group required an additional bone augmentation at implant placement, when compared to 7% in the test sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study clearly points out that an alveolar ridge preservation technique performed with collagenated porcine bone and a resorbable membrane \u2013 according to the procedure reported in this study \u2013 was able to limit the contour changes after tooth extraction. Finally, the test sites showed a better preservation of facial keratinized tissue when compared to control sites; grafted sites allowed the placement of longer and wider implants when compared to implants inserted in non\u2010grafted sites.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0501.2012.02535.x","type":"journal-article","created":{"date-parts":[[2012,7,12]],"date-time":"2012-07-12T05:21:09Z","timestamp":1342070469000},"page":"1231-1237","source":"Crossref","is-referenced-by-count":150,"title":["Tissue changes of extraction sockets in humans: a comparison of spontaneous healing vs. ridge preservation with secondary soft tissue healing"],"prefix":"10.1111","volume":"24","author":[{"given":"Antonio","family":"Barone","sequence":"first","affiliation":[{"name":"Department of Surgery University of Pisa  Pisa Italy"},{"name":"Istituto Stomatologico Tirreno Versilia General Hospital  Lido di Camaiore (LU) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Ricci","sequence":"additional","affiliation":[{"name":"Istituto Stomatologico Tirreno Versilia General Hospital  Lido di Camaiore (LU) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Tonelli","sequence":"additional","affiliation":[{"name":"Department of Dentistry University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Santini","sequence":"additional","affiliation":[{"name":"Istituto Stomatologico Tirreno Versilia General Hospital  Lido di Camaiore (LU) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugo","family":"Covani","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pisa  Pisa Italy"},{"name":"Istituto Stomatologico Tirreno Versilia General Hospital  Lido di Camaiore (LU) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"205","article-title":"Augmentation of the deformed residual edentulous ridge for fixed prosthesis","volume":"1","author":"Abrams L.","year":"1980","journal-title":"Compendium of Continuing Education in General Dentistry"},{"key":"e_1_2_6_3_1","first-page":"123","article-title":"The influence of Bio\u2010Oss collagen on healing of an extraction socket: an experimental study in the dog","volume":"28","author":"Ara\u00fajo M.","year":"2008","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00726.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.6.1015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070628"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02084.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100286"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.8.920"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1988.tb02129.x"},{"key":"e_1_2_6_11_1","first-page":"259","article-title":"GBR in human extraction sockets and ridge defects prior to implant placement: clinical results and histologic evidence of osteoblastic and osteoclastic activities in DFDBA","volume":"19","author":"Brugnami F.","year":"1999","journal-title":"International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.110035"},{"key":"e_1_2_6_13_1","first-page":"469","article-title":"Preservation of the post\u2010extraction alveolar ridge: a clinical and histologic study","volume":"28","author":"Cardaropoli D.","year":"2008","journal-title":"International Journal of Periodontics Restorative Dentistry"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.00895.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.140201.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01584.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027011799.x"},{"key":"e_1_2_6_18_1","first-page":"260","article-title":"Ridge preservation techniques for implant therapy","volume":"24","author":"Darby I.","year":"2009","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090342"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.6.902"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.7.990"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.1969.tb06001.x"},{"key":"e_1_2_6_23_1","first-page":"140","article-title":"Socket seal surgery combined with immediate implant placement: a novel approach for single\u2010tooth replacement","volume":"17","author":"Landsberg C.J.","year":"1997","journal-title":"International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.9.1044"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.6.563"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(67)90046-7"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.09.015"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2009.00176.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(99)90015-0"},{"key":"e_1_2_6_30_1","first-page":"313","article-title":"Bone healing and soft tissue contour changes following single\u2010tooth extraction: a clinical and radiographic 12\u2010month prospective study","volume":"23","author":"Schropp L.","year":"2003","journal-title":"International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.00970.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01311.x"},{"key":"e_1_2_6_33_1","first-page":"159","article-title":"Treatment of dehiscences and fenestrations around dental implants using resorbable and nonresorbable membranes associated with bone autografts: a comparative clinical study","volume":"12","author":"Simion M.","year":"1997","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1966.37.2.117"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02064.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01246.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01482.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1963.34.6.487"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.3.141"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0501.2012.02535.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0501.2012.02535.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:19:32Z","timestamp":1696245572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0501.2012.02535.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,12]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/j.1600-0501.2012.02535.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0501.2012.02535.x","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,12]]}}}