{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:19:00Z","timestamp":1793276340041,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"s6","license":[{"start":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T00:00:00Z","timestamp":1350000000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The objective of the present review was to analyze the literature with regard to the need for keratinized mucosa around implants to maintain health and tissue stability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Human and animal studies were identified through electronic and hand searches. Predetermined outcome measures were (i) implant loss, (ii) peri\u2010implant health, (iii) oral hygiene, (iv) soft\u2010tissue recession, (v) change in marginal bone level, and (vi) patient\u2010centered outcomes. With respect to outcome variables, change in \u201cattachment level\u201d, soft\u2010tissue recession and change in peri\u2010implant bone level were only retrieved from longitudinal studies. For remaining parameters, cross\u2010sectional studies were also considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nineteen relevant publications were identified (17 human and 2 animal studies). Due to marked heterogeneity in study design and reported data, no statistical analysis of retrieved data was feasible. Twelve human studies reported plaque scores for sites with \u201cadequate\u201d (\u22652\u00a0mm) and \u201cinadequate\u201d (&lt;2\u00a0mm) width of keratinized mucosa, and in five studies, an \u201cinadequate\u201d width was associated with a significant higher plaque score. Half of the studies showed significantly higher bleeding scores at implants with &lt;\u00a02\u00a0mm of keratinized mucosa, while the majority of publications (8 of 10) found no differences for probing depths. Two of three longitudinal studies reporting on recessions described no long\u2010term differences with regard to the amount of keratinized mucosa. Evidence on the effect of keratinized mucosa on bone\u2010level changes or implant loss was scarce, and no conclusions could be drawn. No article reporting patient\u2010centered outcomes could be identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Collectively, the findings of this review show that evidence in support of the need for keratinized tissues around implants to maintain health and tissue stability is limited.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1600-0501.2012.02540.x","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T11:14:40Z","timestamp":1350040480000},"page":"136-146","source":"Crossref","is-referenced-by-count":198,"title":["Is there a need for keratinized mucosa around implants to maintain health and tissue stability?"],"prefix":"10.1111","volume":"23","author":[{"given":"Jan L.","family":"Wennstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Periodontology Institute of Odontology The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Derks","sequence":"additional","affiliation":[{"name":"Department of Periodontology Institute of Odontology The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,12]]},"reference":[{"key":"e_1_2_7_1_2_2_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-09-00035.1"},{"key":"e_1_2_7_1_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01178.x"},{"key":"e_1_2_7_1_2_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.070401.x"},{"key":"e_1_2_7_1_2_5_1","first-page":"626","article-title":"Hydroxyapatite\u2010coated cylindrical implants in the posterior mandible: 10\u2010year observations","volume":"11","author":"Block M.S.","year":"1996","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_1_2_6_1","first-page":"323","article-title":"Width of keratinized gingiva and the health status of the supporting tissues around dental implants","volume":"23","author":"Bouri A.","year":"2008","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_1_2_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050393"},{"key":"e_1_2_7_1_2_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100115"},{"key":"e_1_2_7_1_2_9_1","doi-asserted-by":"publisher","DOI":"10.1597\/09-022"},{"key":"e_1_2_7_1_2_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01064.x"},{"key":"e_1_2_7_1_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2008.12.010"},{"key":"e_1_2_7_1_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(85)80056-9"},{"key":"e_1_2_7_1_2_13_1","first-page":"375","article-title":"Clinical evaluation of overdenture restorations supported by osseointegrated titanium implants: a retrospective study","volume":"5","author":"Mericske\u2010Stern R.","year":"1990","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_1_2_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1994.050102.x"},{"key":"e_1_2_7_1_2_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00908.x"},{"key":"e_1_2_7_1_2_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01795.x"},{"key":"e_1_2_7_1_2_17_1","first-page":"317","article-title":"The role of attached gingiva in the health of peri\u2010implant tissue in dogs. 1. Clinical findings","volume":"11","author":"Strub J.R.","year":"1991","journal-title":"The International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_7_1_2_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1995.060301.x"},{"key":"e_1_2_7_1_2_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1994.050101.x"},{"key":"e_1_2_7_1_2_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01492.x"},{"key":"e_1_2_7_2_2_1","first-page":"356","article-title":"A rationale for attached gingiva at the soft\u2010tissue\/implant interface: esthetic and functional dictates","volume":"15","author":"Alpert A.","year":"1994","journal-title":"Compendium of Continuing Education in Dentistry"},{"key":"e_1_2_7_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(90)90531-6"},{"key":"e_1_2_7_2_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1997.080508.x"},{"key":"e_1_2_7_2_5_1","first-page":"117","article-title":"Factors affecting late implant bone loss: a retrospective analysis","volume":"22","author":"Chung D.M.","year":"2007","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01686.x"},{"key":"e_1_2_7_2_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.1.59"},{"key":"e_1_2_7_2_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100318"},{"key":"e_1_2_7_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01479.x"},{"key":"e_1_2_7_2_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11.1856"},{"key":"e_1_2_7_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(86)80011-4"},{"key":"e_1_2_7_2_12_1","first-page":"839","article-title":"Experimental peri\u2010implant tissue breakdown around different dental implant surfaces: clinical and radiographic evaluation in dogs","volume":"19","author":"Martins M.C.","year":"2004","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_3_2_1","first-page":"347","article-title":"Long\u2010term follow\u2010up study of osseointegrated implants in the treatment of totally edentulous jaws","volume":"5","author":"Adell R.","year":"1990","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(86)80010-2"},{"key":"e_1_2_7_3_4_1","first-page":"94","article-title":"The longitudinal effectiveness of osseointegrated dental implants. The Toronto Study: peri\u2010implant mucosal response","volume":"11","author":"Apse P.","year":"1991","journal-title":"The International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_7_3_5_1","unstructured":"Berglundh T.(1993).Studies on gingiva and peri\u2010implant mucosa in the dog. Thesis.University of Gothenburg Sweden."},{"key":"e_1_2_7_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb00520.x"},{"key":"e_1_2_7_3_7_1","first-page":"11","volume-title":"Tissue Integrated Prosteses","author":"Br\u00e5nemark P.\u2010I.","year":"1985"},{"key":"e_1_2_7_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(91)90155-6"},{"key":"e_1_2_7_3_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1990.010105.x"},{"key":"e_1_2_7_3_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01210.x"},{"key":"e_1_2_7_3_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1999.100301.x"},{"key":"e_1_2_7_3_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.707"},{"key":"e_1_2_7_3_13_1","first-page":"303","article-title":"Implant treatment in edentulous maxillae: a 5\u2010year follow\u2010up report on patients with different degrees of jaw resorption","volume":"10","author":"Jemt T.","year":"1995","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_3_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.10.623"},{"key":"e_1_2_7_3_15_1","first-page":"639","article-title":"Survival of the Branemark implant in partially edentulous jaws: a 10\u2010year prospective multicenter study","volume":"14","author":"Lekholm U.","year":"1999","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_3_16_1","first-page":"712","article-title":"The influence of soft tissue thickness on crestal bone changes around implants: a 1\u2010year prospective controlled clinical trial","volume":"24","author":"Linkevicius T.","year":"2009","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.08.018"},{"key":"e_1_2_7_3_18_1","first-page":"28","article-title":"Local risk factors for implant therapy","volume":"24","author":"Martin W.","year":"2009","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_7_3_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.11.859"},{"key":"e_1_2_7_3_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130101.x"},{"key":"e_1_2_7_3_21_1","first-page":"373","article-title":"Soft tissue management during implant maintenance","volume":"12","author":"Rapley J.W.","year":"1992","journal-title":"The International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_7_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0503(81)80007-0"},{"key":"e_1_2_7_3_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01627.x"},{"key":"e_1_2_7_3_24_1","first-page":"145","volume-title":"Tissue Integrated Prostheses","author":"Ten Cate A.R.","year":"1985"},{"key":"e_1_2_7_3_25_1","volume-title":"Oral histology. Development. Structure and function","author":"Ten Cate A.R.","year":"1994"},{"key":"e_1_2_7_3_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(90)90177-E"}],"container-title":["Clinical Oral Implants Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0501.2012.02540.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0501.2012.02540.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T18:36:36Z","timestamp":1694630196000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0501.2012.02540.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":55,"journal-issue":{"issue":"s6","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1600-0501.2012.02540.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0501.2012.02540.x","archive":["Portico"],"relation":{},"ISSN":["0905-7161","1600-0501"],"issn-type":[{"value":"0905-7161","type":"print"},{"value":"1600-0501","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}