{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:52:54Z","timestamp":1788209574778,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"s6","license":[{"start":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T00:00:00Z","timestamp":1350000000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oral Implants Res"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Peri\u2010implantitis is characterized by mucosal inflammation and loss of supporting peri\u2010implant bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this systematic review was to evaluate the efficacy and safety of non\u2010surgical treatment of peri\u2010implantitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>, Embase, and <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>eb of <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cience were searched to identify randomized clinical trial studies that assessed non\u2010surgical treatment of peri\u2010implantitis with a minimum follow\u2010up period of 3\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From a total of 29 abstracts, nine trials were included in this systematic review. Adjunctive local delivery of antibiotics, submucosal glycine powder air polishing, or Er:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser treatment resulted in greater reduction in bleeding on probing compared with submucosal debridement using curettes with adjunctive irrigation with chlorhexidine. In addition, greater reductions in probing depths were found following adjunctive local delivery of antibiotics. The evidence neither supported nor refuted the clinical efficacy of submucosal debridement using curettes or ultrasonic scalers alone. No progressive bone loss was found following any of the assessed treatments over a maximum observation period of 12\u00a0months. Only two studies reported implant survival rates, which were 100% over 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The available evidence suggested that submucosal debridement with adjunctive local delivery of antibiotics, submucosal glycine powder air polishing, or Er:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser treatment may reduce clinical signs of peri\u2010implant mucosal inflammation to a greater extent relative to submucosal debridement using curettes with adjunctive irrigation with chlorhexidine. Long\u2010term randomized controlled trials are needed to assess the efficacy of non\u2010surgical therapy on progressing bone loss, implant survival rates, and measures of oral health\u2010related quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0501.2012.02542.x","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T15:14:40Z","timestamp":1350054880000},"page":"77-83","source":"Crossref","is-referenced-by-count":95,"title":["Non\u2010surgical therapy for the management of peri\u2010implantitis: a systematic review"],"prefix":"10.1111","volume":"23","author":[{"given":"Manoj","family":"Muthukuru","sequence":"first","affiliation":[{"name":"Department of Periodontics University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arbia","family":"Zainvi","sequence":"additional","affiliation":[{"name":"Department of Periodontics University of Washington Seattle WA 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