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Articles published up to December 2011 and those reported on the clinical, radiographic and\/or histological outcome of oral implants subjected to so\u2010called overload were considered eligible for inclusion. Identified studies were assessed by one non\u2010blinded reviewer according to well\u2010defined inclusion and exclusion criteria. When doubt arose, the co\u2010authors were counselled until final agreement was obtained. The\n                      <jats:styled-content style=\"fixed-case\">PICO<\/jats:styled-content>\n                      questions formulated was:\u201cwhat is the effect of overload vs. no overload on bone\/implant loss in clinically stable implants?\u201d\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The database searches as well as additional hand searching, resulted in 726 potentially relevant titles. Eventually, 16 clinical and 25 animal studies were considered relevant to the topic. After inclusion\/exclusion criteria assessment, all clinical studies and all but three animal studies and one systematic review were considered at high risk of bias and excluded. The included animal studies did not reveal an association between overload and peri\u2010implant bone loss in the absence of peri\u2010implant inflammation, whereas in its presence, overload seemed to aggravate the peri\u2010implant tissue breakdown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The effect of implant overload on bone\/implant loss in clinically well\u2010integrated implants is poorly reported and provides little unbiased evidence to support a cause\u2010and\u2010effect relationship. The\n                      <jats:styled-content style=\"fixed-case\">PICO<\/jats:styled-content>\n                      question remained unanswered. At the animal level, \u201coverload\u201d, mimicked by supra\u2010occlusal contacts acting in an uninflamed peri\u2010implant environment, did not negatively affect osseointegration and even was anabolic. In contrast, supra\u2010occlusal contacts in the presence of inflammation significantly increased the plaque\u2010induced bone resorption.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1600-0501.2012.02550.x","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T11:14:40Z","timestamp":1350040480000},"page":"95-107","source":"Crossref","is-referenced-by-count":150,"title":["Occlusal overload and bone\/implant loss"],"prefix":"10.1111","volume":"23","author":[{"given":"Ignace","family":"Naert","sequence":"first","affiliation":[{"name":"KU Leuven, Clinical Unit for Prosthetic Dentistry, BIOMAT KU Leuven Department of Oral Health Sciences &amp; Dental Clinics University Hospitals KU Leuven (Catholic University of Leuven) Kapucijnenvoer 7 blok a bus 7001 BE 3000 Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joke","family":"Duyck","sequence":"additional","affiliation":[{"name":"KU Leuven, Clinical Unit for Prosthetic Dentistry, BIOMAT KU Leuven Department of Oral Health Sciences &amp; Dental Clinics University Hospitals KU Leuven (Catholic University of Leuven) Kapucijnenvoer 7 blok a bus 7001 BE 3000 Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katleen","family":"Vandamme","sequence":"additional","affiliation":[{"name":"KU Leuven, Clinical Unit for Prosthetic Dentistry, BIOMAT KU Leuven Department of Oral Health Sciences &amp; Dental Clinics University Hospitals KU Leuven (Catholic University of Leuven) Kapucijnenvoer 7 blok a bus 7001 BE 3000 Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(81)80077-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01169.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1563\/1548-1336(2003)029<0001:OAALAU>2.3.CO;2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00747.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01307.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1353\/pbm.0.0086"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2007.00038.x"},{"key":"e_1_2_6_9_1","first-page":"1","article-title":"Osseointegrated implants in the treatment of the edentulous jaw. 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