{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:24:50Z","timestamp":1760887490866},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T00:00:00Z","timestamp":1086739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background: <\/jats:bold> The plasminogen activator (PA) system plays many roles in the inflammatory process and tissue remodelling and repair and is considered to play a significant role in periodontal tissue destruction and healing. The aim of this study was to evaluate the role of the PA system in cyclosporin A (CsA)\u2010induced gingival overgrowth in renal transplant patients.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Eighteen renal transplant patients exhibiting moderate to severe CsA\u2010induced gingival overgrowth, 10 other renal transplant patients receiving CsA therapy but showing no sign of CsA\u2010induced gingival overgrowth (CsA\u2010H), 16 chronic gingivitis patients (CG) and 16 systemically and periodontally healthy control subjects (H) were included in the study. Gingival crevicular fluid (GCF) samples were obtained from four randomly selected sites in each subject with the exception of the CsA\u2010induced gingival overgrowth group, where four GCF samples were harvested from sites with severe overgrowth (CsA GO+) and from four sites without any gingival overgrowth (CsA GO\u2212). The GCF levels of albumin, tissue\u2010type plasminogen activator (t\u2010PA), urokinase\u2010type plasminogen activator (u\u2010PA), plasminogen activator inhibitor 1 (PAI\u20101) and plasminogen activator inhibitor 2 (PAI\u20102) were analysed by enzyme\u2010linked immunosorbent assay. The results were tested for statistical differences.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> In CsA GO+ sites t\u2010PA levels were significantly elevated in comparison with gingivitis and healthy sites, while PAI\u20102 levels in these sites showed statistically significant differences only with CsA\u2010H and gingivitis sites (<jats:italic>p<\/jats:italic>&lt;0.05). The levels of t\u2010PA and PAI\u20102 were significantly higher in CsA GO\u2212 sites compared with those of CsA\u2010H, gingivitis and healthy sites (<jats:italic>p<\/jats:italic>&lt;0.05). The levels of u\u2010PA and PAI\u20101 failed to show significant differences between the study groups.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> The findings of the present study indicate alterations in GCF t\u2010PA and PAI\u20102 levels in CsA\u2010induced gingival overgrowth and might suggest involvement of the plasminogen activating system in the pathogenesis of this side\u2010effect of CsA therapy. However, to what extent these molecules contribute to the pathogenesis of CsA\u2010induced gingival overgrowth remains to be determined.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2004.00517.x","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T10:14:48Z","timestamp":1086776088000},"page":"556-561","source":"Crossref","is-referenced-by-count":15,"title":["Plasminogen activators and plasminogen activator inhibitors in gingival crevicular fluid of cyclosporin A\u2010treated patients"],"prefix":"10.1111","volume":"31","author":[{"given":"Nurcan","family":"Buduneli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eralp","family":"Buduneli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sema","family":"\u00c7\u03b9nar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl","family":"Atilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lappin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Kinane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,6,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1995.060102.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1661604"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.4.526"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/000163501317153211"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60028-7"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1999.tb01534.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.170.3962.1095"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00050.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411910020010201"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1993.tb00360.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1996.tb00493.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000469153"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.11.4007.bloodjournal86114007"},{"key":"e_1_2_5_15_1","first-page":"2533","article-title":"Growth factors in the regulation of pericellular proteolysis","volume":"49","author":"Laiho M.","year":"1989","journal-title":"Cancer Research"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199212000-00007"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.11.1092"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90093-4"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.6.548"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb01272.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-419X(85)90014-9"},{"key":"e_1_2_5_22_1","first-page":"905","article-title":"Motivation and education (in German)","volume":"85","author":"Saxer U. 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