{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:33:59Z","timestamp":1769146439831,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,5,10]],"date-time":"2004-05-10T00:00:00Z","timestamp":1084147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background: <\/jats:bold> Treatment with enamel matrix proteins (EMD) or guided tissue regeneration (GTR) has been shown to enhance periodontal regeneration. However, until now there are limited data on the long\u2010term results following these treatment modalities.<\/jats:p><jats:p><jats:bold>Aim: <\/jats:bold> The aim of the present clinical study was to present the 5\u2010year results following treatment of intrabony defects with EMD, GTR, combination of EMD and GTR, and open flap debridement (OFD).<\/jats:p><jats:p><jats:bold>Material and Methods: <\/jats:bold> Forty\u2010two patients, each of whom displayed one intrabony defect of a probing depth of at least 6\u2003mm, were randomly treated with one of the four treatment modalities. The following parameters were evaluated prior to surgery, at 1 year and at 5 years after: plaque index, gingival index, bleeding on probing, probing pocket depth (PPD), gingival recession, and clinical attachment level (CAL). No statistically significant differences in any of the parameters were observed at baseline between the four groups.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> The sites treated with EMD demonstrated a mean CAL gain of 3.4\u00b11.1\u2003mm (<jats:italic>p<\/jats:italic>&lt;0.001) and of 2.9\u00b11.6\u2003mm (<jats:italic>p<\/jats:italic>&lt;0.001) at 1 and 5 years, respectively. The sites treated with GTR showed a mean CAL gain of 3.2\u00b10.8 (<jats:italic>p<\/jats:italic>&lt;0.001) at 1 year and of 2.7\u00b10.9\u2003mm (<jats:italic>p<\/jats:italic>&lt;0.001) at 5 years. The mean CAL gain at sites treated with EMD+GTR was 3.0\u00b11.0\u2003mm (<jats:italic>p<\/jats:italic>&lt;0.001) and 2.6\u00b10.7\u2003mm (<jats:italic>p<\/jats:italic>&lt;0.001) at 1 and 5 years, respectively. The sites treated with OFD demonstrated a mean CAL gain of 1.6\u00b11.0\u2003mm (<jats:italic>p<\/jats:italic>&lt;0.001) at 1 year and 1.3\u00b11.2\u2003mm (<jats:italic>p<\/jats:italic>&lt;0.001) at 5 years. At 1 year, the only statistically significant difference between the four different treatments was found in terms of PPD reduction and CAL gain between EMD and OFD (<jats:italic>p<\/jats:italic>&lt;0.05). However, at 5 years there were no statistically significant differences in any of the investigated parameters between the four different treatments.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> Within the limits of the present study, it may be concluded that the short\u2010term clinical results following treatment with EMD, GTR, EMD+GTR, and OFD can be maintained over a period of 5 years.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2004.00518.x","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T10:14:48Z","timestamp":1086776088000},"page":"545-549","source":"Crossref","is-referenced-by-count":73,"title":["Five\u2010year results following treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration"],"prefix":"10.1111","volume":"31","author":[{"given":"Anton","family":"Sculean","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaos","family":"Donos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Brecx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole B.","family":"Arweiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.12.675"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1980.tb01965.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.3.217"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb00542.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.291007.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.1.25"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb00854.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1997.00855.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/j.1600-051X.1997.tb00253.x","article-title":"Enamel matrix derivative (Emdogain\u00ae) in the treatment of intrabony periodontal defects","volume":"24","author":"Heijl L.","year":"1997","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.2.93"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1967.38.6.610"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1982.tb02095.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.12.1821"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1997.00833.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1987.tb02249.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1999.tb02259.x"},{"key":"e_1_2_5_18_1","first-page":"375","article-title":"Clinical and histologic evaluation of treatment of intrabony defects with an enamel matrix protein derivative (Emdogain\u00ae)","volume":"20","author":"Sculean A.","year":"2000","journal-title":"The International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_5_19_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1902\/jop.1999.70.3.255","article-title":"Comparison of enamel matrix proteins an bioabsorbable membranes in the treatment of intrabony defects. 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