{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:18:26Z","timestamp":1777695506410,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,7,15]],"date-time":"2004-07-15T00:00:00Z","timestamp":1089849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives: <\/jats:bold> Subcutaneous and intramuscular implants of bone morphogenetic protein\u201012 (BMP\u201012) have been shown to induce formation of tendon and ligament tissue. BMP\u201012 induced a new attachment with a distinct fibrocartilaginous zone at the tendon\u2010bone interface in the rat tendon\u2010bone attachment model. Surgical controls showed poor healing and failure to reform the appropriate tendon\u2013bone attachment morphologically. Application of recombinant human BMP\u201012 (rhBMP\u201012) to periodontal defects suggests that rhBMP\u201012 has the potential to support regeneration of the periodontal ligament (PDL). The objective of this pilot study was to evaluate this effect of rhBMP\u201012 in a tooth replantation model.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Six, young adult, male Hound Labrador mongrel dogs were used. Maxillary and\/or mandibular incisor and premolar teeth were extracted and the PDL was either left \u201cintact\u201d or removed by root planing. rhBMP\u201012 (1.0\u2003mg\/ml) or a buffer control was topically applied to teeth with \u201cintact\u201d PDL in contralateral jaw quadrants in each of 3 animals. The teeth were immersed in 1.0\u2003ml of the rhBMP\u201012 or the buffer solution for 10\u2003min and then replanted. The remaining three animals received rhBMP\u201012 (1.0\u2003mg\/ml) and the buffer control in a similar fashion applied to teeth instrumented to remove the PDL and cementum, and surface demineralized with citric acid. The animals were euthanized at 8 weeks postsurgery and block sections were collected and processed for histopathologic analysis.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> No dramatic differences were found between teeth receiving topical rhBMP\u201012 and the buffer control. Application of rhBMP\u201012 did not have an apparent effect on new cementum and PDL formation in the tooth replantation model. Moreover, application of rhBMP\u201012 did not increase nor did it decrease the apparent presence and extent of ankylosis along the root surface compared to the control.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> The observations from this study do not support the use of topical rhBMP\u201012 to support the reestablishment of the PDL including regeneration of cementum and functionally oriented fibers, and to prevent ankylosis and root resorption following replantation of teeth.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2004.00540.x","type":"journal-article","created":{"date-parts":[[2004,7,15]],"date-time":"2004-07-15T09:56:32Z","timestamp":1089885392000},"page":"654-661","source":"Crossref","is-referenced-by-count":27,"title":["Effect of recombinant human bone morphogenetic protein\u201012 (rhBMP\u201012) on regeneration of periodontal attachment following tooth replantation in dogs"],"prefix":"10.1111","volume":"31","author":[{"given":"Rachel G.","family":"Sorensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Polimeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhiro","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Wozney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf M. 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