{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T18:24:41Z","timestamp":1780424681285,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,8,12]],"date-time":"2004-08-12T00:00:00Z","timestamp":1092268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background: <\/jats:bold> Recombinant human bone morphogenetic protein\u20102 (rhBMP\u20102) has been shown to induce clinically relevant bone formation for orthopedic, craniofacial, and oral indications. It appears critical, in particular for onlay indications, that the associated carrier technology exhibits structural integrity to offset compressive forces in support of rhBMP\u20102\u2010induced bone formation. The objective of this study was to evaluate a calcium phosphate (CP) cement, Ceredex\u2122, as a candidate carrier for rhBMP\u20102 in a defect model with limited osteogenic potential.<\/jats:p><jats:p><jats:bold>Materials: <\/jats:bold> Bilateral, critical size, 6\u2010mm, supra\u2010alveolar, periodontal defects were created in six, adult, male, Hound Labrador mongrels. Three animals received rhBMP\u20102\/Ceredex\u2122 (rhBMP\u20102 at 0.20 and 0.40\u2003mg\/ml) in contralateral defect sites (implant volume\/defect \u223c1\u2003ml). One defect site in each of the three remaining animals received Ceredex\u2122 without rhBMP\u20102 (control). The animals were euthanized at 12 weeks postsurgery for histologic and histometric analysis.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Mean induced bone height exceeded 80% of the defect height for supra\u2010alveolar periodontal defects receiving rhBMP\u20102\/Ceredex\u2122 without major differences between rhBMP\u20102 concentrations compared with approximately 40% for the control. The newly formed bone, a mixture of lamellar and woven bone in fibrovascular tissue, circumscribed relatively large portions of the residual Ceredex\u2122 biomaterial. Inflammatory lesions were associated with limited bone formation in some sites. From a periodontal perspective, sites receiving rhBMP\u20102\/Ceredex\u2122 exhibited increased cementum formation compared with control, but without a functionally oriented periodontal ligament, and increased ankylosis and root resorption. Control sites exhibited early wound failure and exposure, loss of the Ceredex\u2122 biomaterial, and limited bone formation.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> The Ceredex\u2122 CP cement appears a potentially promising carrier technology for rhBMP\u20102 onlay indications. However, a slow resorption rate may prevent its wider use. This study does not support use of the rhBMP\u20102\/Ceredex\u2122 combination for periodontal indications.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2004.00544.x","type":"journal-article","created":{"date-parts":[[2004,8,12]],"date-time":"2004-08-12T15:57:05Z","timestamp":1092326225000},"page":"796-804","source":"Crossref","is-referenced-by-count":61,"title":["Periodontal repair in dogs: evaluation of a bioresorbable calcium phosphate cement (Ceredex<sup>TM<\/sup>) as a carrier for rhBMP\u20102"],"prefix":"10.1111","volume":"31","author":[{"given":"Rachel G.","family":"Sorensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf M. 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